Asad M, Shewade D G, Koumaravelou K, Abraham B K, Vasu S, Ramaswamy S
Department of Pharmacology, Jawaharlal Institute of Post-graduate Medical Education and Research, Pondicherry 605 006, India.
Acta Pharmacol Sin. 2001 Jun;22(6):488-92.
To investigate the effect of centrally administered oxytocin and its receptor antagonist, atosiban, on gastric acid secretion and on experimentally induced gastric and duodenal ulcers.
The acute gastric ulcer models, such as pylorus ligation, indomethacin-induced and ethanol-induced gastric ulcers were used. Chronic gastric ulcers were induced by acetic acid and duodenal ulcers by cysteamine HCl.
In pylorus ligated rats, oxytocin (10 microg/kg, icv) showed significant antisecretory and antiulcer activity (P < 0.01). However, it aggravated the ethanol-induced gastric ulcers and did not show any effect on indomethacin-induced gastric ulcers. Oxytocin increased gastric ulcer healing in acetic acid-induced chronic gastric ulcers. The effect of oxytocin was reversed by atosiban (10 microg/kg, icv), a selective oxytocin receptor antagonist. Atosiban when given alone increased gastric acid secretion and ulcer index in pylorus-ligated rats and also aggravated acetic acid-induced chronic gastric ulcers. It seems the antiulcer activity of oxytocin was due to its anti-secretory effect.
Centrally administered oxytocin possesses gastric anti-secretory and anti-ulcer activity and oxytocin antagonist, atosiban, is pro-ulcerogenic in rats.
研究中枢给予催产素及其受体拮抗剂阿托西班对胃酸分泌以及实验性诱导的胃溃疡和十二指肠溃疡的影响。
采用急性胃溃疡模型，如幽门结扎、吲哚美辛诱导和乙醇诱导的胃溃疡模型。用乙酸诱导慢性胃溃疡，用盐酸半胱胺诱导十二指肠溃疡。
在幽门结扎的大鼠中，催产素（10微克/千克，脑室内注射）显示出显著的抗分泌和抗溃疡活性（P<0.01）。然而，它加重了乙醇诱导的胃溃疡，对吲哚美辛诱导的胃溃疡没有任何作用。催产素促进了乙酸诱导的慢性胃溃疡的愈合。催产素的作用被选择性催产素受体拮抗剂阿托西班（10微克/千克，脑室内注射）逆转。单独给予阿托西班会增加幽门结扎大鼠的胃酸分泌和溃疡指数，也会加重乙酸诱导的慢性胃溃疡。催产素的抗溃疡活性似乎归因于其抗分泌作用。
中枢给予催产素具有胃抗分泌和抗溃疡活性，而催产素拮抗剂阿托西班在大鼠中具有促溃疡作用。
