Therapeutic Chemistry Department, National Research Center, El-Tahrir St,, Dokki, Cairo, 12311, Egypt.
Nutr Metab (Lond). 2011 Jun 20;8:40. doi: 10.1186/1743-7075-8-40.
BACKGROUND/OBJECTIVE: Zingiber officinale Roscoe (ginger) (Zingiberaceae) has been cultivated for thousands of years both as a spice and for medicinal purposes. Ginger rhizomes successive extracts (petroleum ether, chloroform and ethanol) were examined against liver fibrosis induced by carbon tetrachloride in rats.
The evaluation was done through measuring antioxidant parameters; glutathione (GSH), total superoxide dismutase (SOD) and malondialdehyde (MDA). Liver marker enzymes; succinate and lactate dehydrogenases (SDH and LDH), glucose-6-phosphatase (G-6-Pase), acid phosphatase (AP), 5'- nucleotidase (5'NT) and liver function enzymes; aspartate and alanine aminotransferases (AST and ALT) as well as cholestatic markers; alkaline phosphatase (ALP), gamma glutamyl transferase (GGT), total bilirubin were estimated. Liver histopathological analysis and collagen content were also evaluated. Treatments with the selected extracts significantly increased GSH, SOD, SDH, LDH, G-6-Pase, AP and 5'NT. However, MDA, AST, ALT ALP, GGT and total bilirubin were significantly decreased.
Extracts of ginger, particularly the ethanol one resulted in an attractive candidate for the treatment of liver fibrosis induced by CCl4. Further studies are required in order to identify the molecules responsible of the pharmacological activity.
背景/目的：姜（姜科）已被种植了几千年，既是香料，也可药用。对生姜根茎连续提取物（石油醚、氯仿和乙醇）进行了四氯化碳诱导的大鼠肝纤维化的抑制作用评价。
通过测量抗氧化参数（谷胱甘肽[GSH]、总超氧化物歧化酶[SOD]和丙二醛[MDA]）进行评估。肝标记酶（琥珀酸和乳酸脱氢酶[SDH 和 LDH]、葡萄糖-6-磷酸酶[G-6-Pase]、酸性磷酸酶[AP]、5'-核苷酸酶[5'NT]）和肝功能酶（天冬氨酸和丙氨酸氨基转移酶[AST 和 ALT]）以及胆汁淤积标志物（碱性磷酸酶[ALP]、γ-谷氨酰转移酶[GGT]、总胆红素）也进行了评估。还进行了肝组织病理学分析和胶原含量评估。所选提取物的治疗显著增加了 GSH、SOD、SDH、LDH、G-6-Pase、AP 和 5'NT。然而，MDA、AST、ALT、ALP、GGT 和总胆红素显著降低。
生姜提取物，特别是乙醇提取物，可能是治疗 CCl4 诱导的肝纤维化的一种有吸引力的候选药物。需要进一步研究以确定具有药理活性的分子。
