Stefancíková A, Pet'ko B, Rozická I, Salyová N, Ohlasová D
Parasitological Institute of the Slovak Academy of Sciences, Hlinkova 3, 040 01 Kosice, Slovak Republic.
Ann Agric Environ Med. 2001;8(2):171-5.
439 sera of patients from eastern Slovakia suspected of Lyme borreliosis were examined for anti-Borrelia IgG and IgM antibodies by ELISA (Ezygnost, Dade Behring, Germany). Out of the total number of 64 sera, e.g. in 14.6% found anti-Borrelia antibodies were. Among seropositive patients, 54.7% were women and 45.3% men. The highest incidence of the disease was diagnosed in the group of women aged 55-64 and men aged 45-54. Out of 29 positive sera of men, 55.2% had IgG antibodies, 27.6% IgM antibodies and 17.2% both types of antibodies. Out of 35 positive sera of women, 48.6% had IgG antibodies, 40.0% IgM antibodies and 11.4% both types of antibodies. Erythema Chronicum Migrans--ECM (31.3%) and arthritis (25.0%) prevailed among clinical symptoms, in contrast with only 7.8% of neurological cases. In men, arthritis most frequently occurred (27.6%), while in women erythema migrans forms (37.1%). Other manifestations of the disease appeared in 13 patients (20.3%), and 10 patients (15.6%) had no record of clinical manifestations. As shown by patients' records, 32.8% reported attachment of tick, 20.3% insect bites and 29.7% were not aware of being bitten by vectors. Seasonal dynamics of diagnosed cases reached three peaks with the highest numbers in February, May and October.
采用酶联免疫吸附测定法（Ezygnost，德国达德拜灵公司）对来自斯洛伐克东部疑似莱姆病的439例患者血清进行抗伯氏疏螺旋体IgG和IgM抗体检测。在总共64份血清中，即14.6%的血清检测到抗伯氏疏螺旋体抗体。在血清阳性患者中，女性占54.7%，男性占45.3%。该病发病率最高的是55 - 64岁的女性组和45 - 54岁的男性组。在29份男性阳性血清中，55.2%含有IgG抗体，27.6%含有IgM抗体，17.2%同时含有两种抗体。在35份女性阳性血清中，48.6%含有IgG抗体，40.0%含有IgM抗体，11.4%同时含有两种抗体。慢性游走性红斑——ECM（31.3%）和关节炎（25.0%）是主要临床症状，相比之下，神经系统病例仅占7.8%。在男性中，关节炎最为常见（27.6%），而在女性中，游走性红斑形式最为常见（37.1%）。该病的其他表现出现在13例患者中（20.3%），10例患者（15.6%）无临床表现记录。患者记录显示，32.8%的人报告有蜱虫附着，20.3%的人报告有昆虫叮咬，29.7%的人不清楚被病媒叮咬过。确诊病例的季节动态呈现三个高峰，2月、5月和10月的病例数最多。
