Lischer Ch J, Koller U, Geyer H, Mülling Ch, Schulze J, Ossent P
Department of Veterinary Surgery, University of Zurich, Winterthurerstrasse 260, Zürich, 8057, Switzerland.
Vet J. 2002 Jan;163(1):51-60. doi: 10.1053/tvjl.2001.0627.
The objective of this study was to investigate the influence of orally administered biotin on the healing of uncomplicated sole ulcers in dairy cattle. In a double-blind controlled study, 24 dairy cows with a mild, uncomplicated sole ulcer on a lateral hind claw were given either 40 mg biotin per day or a placebo feed over a period of 50 days. An orthopaedic shoe was fitted to the medial claw of the affected foot. The healing process was assessed clinically and by histological examination of horn samples. In the biotin-treated animals, the newly formed epidermis covering the sole ulcers was found to be of significantly better histological quality after 50 days than at the start of the study. The significant improvement in histological horn quality found in the biotin-treated animals suggests that biotin exerts a positive influence on the healing of sole ulcers, however the study period of 50 days appears to have been too short to permit macroscopic detection of the improvement in horn quality.
本研究的目的是调查口服生物素对奶牛单纯性蹄底溃疡愈合的影响。在一项双盲对照研究中，24头后肢外侧爪患有轻度单纯性蹄底溃疡的奶牛，在50天的时间里，每天给予40毫克生物素或安慰剂饲料。给患侧蹄的内侧爪安装了矫形蹄铁。通过临床评估和角样本的组织学检查来评估愈合过程。在接受生物素治疗的动物中，发现覆盖蹄底溃疡的新形成的表皮在50天后的组织学质量明显优于研究开始时。在接受生物素治疗的动物中发现的组织学角质量的显著改善表明，生物素对蹄底溃疡的愈合有积极影响，然而50天的研究期似乎太短，无法从宏观上检测到角质量的改善。
