Madden W S, Landells I D, Poulin Y, Searles G E, Smith K C, Tan J K, Toole J, Zip C M, Degreef H
Universtiy of British Columbia, Vancouver, British Columbia, Canada.
J Cutan Med Surg. 2000 Jun;4 Suppl 1:S2-13.
Acne affects approximately 95% of the population at some point during their lifetime.1 This common disorder can range from mild to severe forms, cause sometimes extensive scarring, and can last well into the fourth and fifth decades. Effective therapeutic agents are available to both treat acne and prevent ongoing disease. Despite this, dermatologists frequently see patients with significant acne scarring because many patients delay seeking medical attention for acne and many practitioners procrastinate over using effective antiscarring options. In patients who already demonstrate scarring, repeated courses of antibiotics only result in recurring acne and additional scarring. This, in turn, exacerbates the despair and other adverse psychosocial effects of the disease. There are a variety of agents and devices to help acne patients with scarring. However, successful treatment cannot be guaranteed, and in most cases residual scarring will be evident. Thus, the most effective way of managing acne scarring is to prevent its occurrence in the first place. Although we currently have a number of effective antiacne agents to control the disease, such as antibiotics and hormonal agents, isotretinoina is the only agent that has been shown to induce long-term drug-free remission and curative potential.
痤疮在一生中的某个阶段会影响约95%的人群。这种常见疾病的严重程度不一,从轻症到重症都有,有时会导致大面积疤痕,且可持续到四五十岁。目前有有效的治疗药物可用于治疗痤疮并预防疾病进展。尽管如此,皮肤科医生仍经常见到有严重痤疮疤痕的患者,因为许多患者推迟寻求痤疮治疗,而且许多医生也拖延使用有效的抗疤痕治疗方法。对于已经出现疤痕的患者,反复使用抗生素只会导致痤疮复发和更多疤痕形成。这反过来又会加剧患者的绝望情绪以及该疾病带来的其他不良社会心理影响。有多种药物和设备可帮助有疤痕的痤疮患者。然而,无法保证治疗一定成功,在大多数情况下,残留疤痕仍会很明显。因此,管理痤疮疤痕最有效的方法是首先预防其发生。虽然我们目前有多种有效的抗痤疮药物来控制病情,如抗生素和激素类药物,但异维甲酸是唯一已被证明能诱导长期无药缓解且具有治愈潜力的药物。