• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

皮内黑色素瘤转移灶的瘤内卡介苗治疗相关的肺转移疾病消退

Regression of pulmonary metastatic disease associated with intralesional BCG therapy of intracutaneous melanoma metastases.

作者信息

Mastrangelo M J, Bellet R E, Berkelhammer J, Clark W H

出版信息

Cancer. 1975 Oct;36(4):1305-8. doi: 10.1002/1097-0142(197510)36:4<1305::aid-cncr2820360417>3.0.co;2-#.

DOI:10.1002/1097-0142(197510)36:4<1305::aid-cncr2820360417>3.0.co;2-#
PMID:1175129
Abstract

A 77-year-old white man with 64 intracutaneous melanoma metastases and a pulmonary metastatic deposit was treated with immunotherapy. Over an 8-month period, 17 intracutaneous lesions were inoculated with BCG. All 17 injected lesions and all 47 uninjected intracutaneous lesions resolved; no new nodules appeared and the pulmonary metastasis regressed (greater than 50%). This is the first documented case of a pulmonary metastatic focus responding to intralesional BCG therapy of intracutaneous metastases.

摘要

一名77岁的白人男性，患有64处皮肤黑色素瘤转移灶及一处肺转移瘤，接受了免疫治疗。在8个月的时间里，对17处皮肤病变接种了卡介苗。所有17处注射病变及所有47处未注射的皮肤病变均消退；未出现新的结节，肺转移瘤缩小（超过50%）。这是首例有记录的肺转移灶对皮肤转移灶的病灶内卡介苗治疗产生反应的病例。

相似文献

1
Regression of pulmonary metastatic disease associated with intralesional BCG therapy of intracutaneous melanoma metastases.皮内黑色素瘤转移灶的瘤内卡介苗治疗相关的肺转移疾病消退
Cancer. 1975 Oct;36(4):1305-8. doi: 10.1002/1097-0142(197510)36:4<1305::aid-cncr2820360417>3.0.co;2-#.
2
Complete remission of metastatic malignant melanoma following immunotherapy with Bacillus Calmette-Guerin (BCG): report of a case.卡介苗（BCG）免疫治疗后转移性恶性黑色素瘤完全缓解：一例报告
Aust N Z J Surg. 1977 Jun;47(3):362-5. doi: 10.1111/j.1445-2197.1977.tb04303.x.
3
Immunotherapy of melanoma with BCG: two fatalities following intralesional injection.用卡介苗对黑色素瘤进行免疫治疗：病灶内注射后出现两例死亡病例。
Cancer. 1975 Feb;35(2):514-20. doi: 10.1002/1097-0142(197502)35:2<514::aid-cncr2820350233>3.0.co;2-f.
4
The immunologic and histopathologic changes of BCG-mediated tumor regression in patients with malignant melanoma.恶性黑色素瘤患者中卡介苗介导的肿瘤消退的免疫和组织病理学变化。
Cancer. 1975 Mar;35(3):756-77. doi: 10.1002/1097-0142(197503)35:3<756::aid-cncr2820350331>3.0.co;2-z.
5
Intralesional treatment of recurrent metastatic cutaneous malignant melanoma: a randomized prospective study of intralesional Bacillus Calmette-Guerin versus intralesional dinitrochlorobenzene.复发性转移性皮肤恶性黑色素瘤的病灶内治疗：卡介苗与二硝基氯苯病灶内注射的随机前瞻性研究
Cancer. 1978 Jun;41(6):2456-63. doi: 10.1002/1097-0142(197806)41:6<2456::aid-cncr2820410654>3.0.co;2-b.
6
BCG immunotherapy of malignant melanoma: summary of a seven-year experience.卡介苗免疫疗法治疗恶性黑色素瘤：七年经验总结
Ann Surg. 1974 Oct;180(4):635-43. doi: 10.1097/00000658-197410000-00029.
7
Intralesional immunotherapy of melanoma with BCG.卡介苗对黑色素瘤的瘤内免疫疗法。
Med Clin North Am. 1976 May;60(3):419-30. doi: 10.1016/s0025-7125(16)31889-2.
8
Spontaneous regression of malignant melanoma.恶性黑色素瘤的自发消退
Oncology. 1978;35(2):83-6. doi: 10.1159/000225261.
9
Adjuvant immunotherapy with BCG in treatment of regional-lymph-node metastases from malignant melanoma.卡介苗辅助免疫疗法治疗恶性黑色素瘤区域淋巴结转移
N Engl J Med. 1976 Jan 29;294(5):237-40. doi: 10.1056/NEJM197601292940501.
10
Tumour regression and survival of patients with disseminated malignant melanoma treated with chemotherapy and specific active immunotherapy.接受化疗和特异性主动免疫治疗的播散性恶性黑色素瘤患者的肿瘤消退及生存情况
Eur J Cancer (1965). 1977 Oct;13(10):1169-73. doi: 10.1016/0014-2964(77)90017-2.

引用本文的文献

1
In situ delivery of nanoparticles formulated with micron-sized crystals protects from murine melanoma.载药微米晶体纳米粒原位递药防治小鼠黑素瘤
J Immunother Cancer. 2022 Sep;10(9). doi: 10.1136/jitc-2022-004643.
2
Malignant melanoma: evolving practice management in an era of increasingly effective systemic therapies.恶性黑色素瘤：在全身治疗日益有效的时代中不断发展的实践管理
Curr Probl Surg. 2022 Jan;59(1):101030. doi: 10.1016/j.cpsurg.2021.101030. Epub 2021 Jul 7.
3
Neoadjuvant treatment for melanoma: current challenges and future perspectives.
黑色素瘤的新辅助治疗：当前挑战与未来展望。
Melanoma Manag. 2016 Jun;3(2):149-159. doi: 10.2217/mmt-2015-0001. Epub 2016 May 25.
4
Intralesional treatment for advanced melanoma: what's on the horizon?晚期黑色素瘤的瘤内治疗：未来发展趋势如何？
Melanoma Manag. 2016 Jun;3(2):113-123. doi: 10.2217/mmt-2016-0007. Epub 2016 May 25.
5
Intratumoral infection by CMV may change the tumor environment by directly interacting with tumor-associated macrophages to promote cancer immunity.巨细胞病毒的瘤内感染可能通过与肿瘤相关巨噬细胞直接相互作用来改变肿瘤环境，从而促进癌症免疫。
Hum Vaccin Immunother. 2017 Aug 3;13(8):1778-1785. doi: 10.1080/21645515.2017.1331795. Epub 2017 Jun 12.
6
Intralesional treatment of metastatic melanoma: a review of therapeutic options.转移性黑色素瘤的瘤内治疗：治疗选择综述
Cancer Immunol Immunother. 2017 May;66(5):647-656. doi: 10.1007/s00262-016-1952-0. Epub 2017 Jan 11.
7
Intralesional Immunotherapy for Metastatic Melanoma: The Oldest and Newest Treatment in Oncology.转移性黑色素瘤的瘤内免疫疗法：肿瘤学中最古老也是最新的治疗方法。
Crit Rev Oncog. 2016;21(1-2):65-73. doi: 10.1615/CritRevOncog.2016017124.
8
Immunotherapy in the management of melanoma: current status.黑色素瘤治疗中的免疫疗法：现状
Immunotargets Ther. 2013 Feb 23;2:1-10. doi: 10.2147/ITT.S30824. eCollection 2013.
9
Intralesional therapy for advanced melanoma: promise and limitation.晚期黑色素瘤的瘤内治疗：前景与局限
Curr Opin Oncol. 2015 Mar;27(2):151-6. doi: 10.1097/CCO.0000000000000158.
10
Melanoma vaccines: mixed past, promising future.黑素瘤疫苗：过去喜忧参半，未来充满希望。
Surg Clin North Am. 2014 Oct;94(5):1017-30, viii. doi: 10.1016/j.suc.2014.07.005. Epub 2014 Aug 7.