VmrA是副溶血性弧菌中一类新型的与钠离子偶联的多药外排泵的成员。
VmrA, a member of a novel class of Na(+)-coupled multidrug efflux pumps from Vibrio parahaemolyticus.
作者信息
Chen Jing, Morita Yuji, Huda M Nazmul, Kuroda Teruo, Mizushima Tohru, Tsuchiya Tomofusa
机构信息
Department of Microbiology, Faculty of Pharmaceutical Sciences, Okayama University, Tsushima, Okayama 700-8530, Japan.
出版信息
J Bacteriol. 2002 Jan;184(2):572-6. doi: 10.1128/JB.184.2.572-576.2002.
Abstract
Gene vmrA, cloned from Vibrio parahaemolyticus, made Escherichia coli resistant to 4',6-diamino-2-phenylindol, tetraphenylphosphonium chloride, acriflavine, and ethidium bromide. VmrA belongs to the DinF branch of MATE family efflux transporters. VmrA catalyzed acriflavine efflux and showed Na(+)/drug transporter activity because the addition of tetraphenylphosphonium to Na(+)-loaded cells caused Na(+) efflux.
摘要
从副溶血性弧菌克隆的基因vmrA使大肠杆菌对4',6-二氨基-2-苯基吲哚、氯化四苯基鏻、吖啶黄素和溴化乙锭产生抗性。VmrA属于多药和有毒化合物排出家族（MATE）转运蛋白的DinF分支。VmrA催化吖啶黄素外流，并表现出Na(+)/药物转运活性，因为向加载Na(+)的细胞中添加氯化四苯基鏻会导致Na(+)外流。
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