Guex N, Peitsch M C
Geneva Biomedical Research Institute, Glaxo Wellcome Research and Development, Plan-les-Ouates/Geneva, Switzerland.
Electrophoresis. 1997 Dec;18(15):2714-23. doi: 10.1002/elps.1150181505.
Comparative protein modeling is increasingly gaining interest since it is of great assistance during the rational design of mutagenesis experiments. The availability of this method, and the resulting models, has however been restricted by the availability of expensive computer hardware and software. To overcome these limitations, we have developed an environment for comparative protein modeling that consists of SWISS-MODEL, a server for automated comparative protein modeling and of the SWISS-PdbViewer, a sequence to structure workbench. The Swiss-PdbViewer not only acts as a client for SWISS-MODEL, but also provides a large selection of structure analysis and display tools. In addition, we provide the SWISS-MODEL Repository, a database containing more than 3500 automatically generated protein models. By making such tools freely available to the scientific community, we hope to increase the use of protein structures and models in the process of experiment design.
比较蛋白质建模越来越受到关注，因为它在诱变实验的合理设计中非常有帮助。然而，这种方法及其所得模型的可用性一直受到昂贵计算机硬件和软件可用性的限制。为了克服这些限制，我们开发了一个比较蛋白质建模环境，它由SWISS-MODEL（一个用于自动比较蛋白质建模的服务器）和SWISS-PdbViewer（一个从序列到结构的工作台）组成。SWISS-PdbViewer不仅作为SWISS-MODEL的客户端，还提供大量的结构分析和显示工具。此外，我们还提供了SWISS-MODEL库，这是一个包含3500多个自动生成的蛋白质模型的数据库。通过向科学界免费提供这些工具，我们希望在实验设计过程中增加蛋白质结构和模型的使用。
