49只接受心脏同种异体移植的南非大狒狒的形态学变化。
Morphological changes in 49 chacma baboons after cardiac allografts.
作者信息
Rose A G, Uys C J, Losman J G, Barnard C N
出版信息
S Afr Med J. 1979 Nov 24;56(22):880-6.
The morhpological changes in 49 chacma baboons after cardiac transplantation were studied by light and electron microscopy. Non-immunosuppressed grafts were tolerated for an average of 10 days and immunosuppressed grafts for 18 days. Serial biopsy specimens of non-immunosuppressed grafts showed a progression in severity of rejection changes. Electron microscopy mirrored the light microscopic changes. Rejection changes in the baboon appear similar to those encountered in human and canine allografts. Heterotopic transplants showed more severe grades of rejection than would be compatible with life in orthotopic transplants.
通过光学显微镜和电子显微镜研究了49只南非大狒狒心脏移植后的形态学变化。未进行免疫抑制的移植物平均耐受10天，进行免疫抑制的移植物耐受18天。未进行免疫抑制的移植物的系列活检标本显示排斥反应变化的严重程度呈进展性。电子显微镜结果与光学显微镜变化一致。狒狒的排斥反应变化与人及犬类同种异体移植物中观察到的变化相似。异位移植的排斥反应程度比原位移植中与存活相容的程度更严重。
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