Losman J G, Rose A G, Barnard C N
Transplantation. 1977 May;23(5):414-22. doi: 10.1097/00007890-197705000-00006.
The relationship between alterations in myocardial fibrinolytic activity and the degree of graft tolerance or rejection was studied in 22 nonimmunosuppressed heterotopic cardiac transplants in chacma baboons. Fibrinolysis was evaluated on tissue sections and tissue extracts. Fibrinolytic activity was compared with electrocardiographic voltage alterations and multiple myocardial biopsies and terminal heart specimens were examined by light and electron microscopy. Histopathology and reduction in fibrinolytic activity proved superior to electrocardiographic voltage reductions in assessing early cardiac rejection. The two former modalities correlated well with one another. Myocardial histology showed rejection change earlier than fibrinolytic activity reduction.
在22只未接受免疫抑制的南非大狒狒异位心脏移植中，研究了心肌纤溶活性改变与移植耐受或排斥程度之间的关系。在组织切片和组织提取物上评估纤溶情况。将纤溶活性与心电图电压改变进行比较，并通过光镜和电镜检查多次心肌活检及终末期心脏标本。在评估早期心脏排斥方面，组织病理学和纤溶活性降低比心电图电压降低更具优势。前两种方式彼此相关性良好。心肌组织学显示排斥变化比纤溶活性降低更早出现。
