Moodley Prashini, Connolly Cathy, Sturm A Willem
Africa Centre for Population Studies and Reproductive Health and Department of Medical Microbiology, Faculty of Medicine, University of Natal, Durban, South Africa.
J Infect Dis. 2002 Jan 1;185(1):69-73. doi: 10.1086/338027. Epub 2001 Dec 4.
Vaginal discharge of mixed etiology occurs frequently, with abnormal vaginal flora being the most common condition. The interrelationships among the disturbance of the vaginal ecology, the presence of yeasts, and infection with Trichomonas vaginalis and human immunodeficiency virus type 1 (HIV-1) were investigated among women presenting to a sexually transmitted diseases service. Analysis was done for 598 women. Although the prevalence of HIV-1 infection increased linearly with increasing Nugent's score (bacterial vaginosis score of Gram stain), the prevalence of T. vaginalis increased suddenly, from 12% in patients with a Nugent's score of < or =3 to 33% in patients with a score of 4, and remained at this level at higher scores. Yeast colonization and vulvovaginal candidiasis were inversely related to Nugent's scores. T. vaginalis might be responsible for the change in normal vaginal flora and may, therefore, be one of the causes of bacterial vaginosis. This could lead to more effective HIV-1 acquisition.
多种病因导致的阴道分泌物异常很常见，其中阴道菌群异常是最常见的情况。我们在一家性传播疾病诊所就诊的女性中，研究了阴道生态紊乱、酵母菌存在、阴道毛滴虫感染与1型人类免疫缺陷病毒（HIV-1）感染之间的相互关系。对598名女性进行了分析。虽然HIV-1感染率随 Nugent评分（革兰氏染色的细菌性阴道病评分）升高呈线性增加，但阴道毛滴虫感染率突然上升，从 Nugent评分≤3的患者中的12%升至评分为4的患者中的33%，且在更高评分时保持在这一水平。酵母菌定植和外阴阴道念珠菌病与 Nugent评分呈负相关。阴道毛滴虫可能是导致正常阴道菌群变化的原因之一，因此可能是细菌性阴道病的病因之一。这可能导致HIV-1更容易感染。
