Wanahita Anna, Goldsmith Elizabeth A, Musher Daniel M, Clarridge Jill E, Rubio Jose, Krishnan Bhuvaneswari, Trial JoAnn
Medical Service, Veterans Affairs Medical Center, Baylor College of Medicine, Houston, TX 77030, USA.
J Infect Dis. 2002 Jan 1;185(1):85-90. doi: 10.1086/338145. Epub 2001 Dec 6.
Because Streptococcus milleri group (SMG) bacteria--Streptococcus constellatus, Streptococcus intermedius, and Streptococcus anginosus--exhibit a striking propensity to cause abscesses, the interaction of these organisms with human polymorphonuclear leukocytes (PMNL) was examined. After incubation in pooled normal human serum, SMG stimulated less chemotaxis than did Staphylococcus aureus, in contrast to viridans streptococci, which caused greater chemotaxis than did S. aureus. PMNL ingested greater numbers of SMG and viridans streptococci than S. aureus but killed these organisms more slowly and less completely. Relative resistance to killing by PMNL is expected in organisms that cause abscesses, and inhibition of chemotaxis may contribute to pathogenicity, because delayed arrival of PMNL gives a head start to proliferating bacteria. This study helps explain the capacity of SMG to cause abscesses. It is unclear, however, why viridans streptococci, bacteria that rarely produce abscesses, share some of these same properties.
由于米勒链球菌群（SMG）细菌——星座链球菌、中间链球菌和咽峡炎链球菌——具有引发脓肿的显著倾向，因此对这些微生物与人类多形核白细胞（PMNL）的相互作用进行了研究。在正常人混合血清中孵育后，与甲型溶血性链球菌相比，SMG刺激的趋化作用较弱，而甲型溶血性链球菌引起的趋化作用比金黄色葡萄球菌更强。PMNL摄取的SMG和甲型溶血性链球菌数量比金黄色葡萄球菌更多，但杀死这些微生物的速度更慢且不完全。预计导致脓肿的微生物对PMNL的杀伤具有相对抗性，趋化作用的抑制可能有助于致病性，因为PMNL的延迟到达会使增殖细菌获得先机。这项研究有助于解释SMG引发脓肿的能力。然而，尚不清楚为什么很少产生脓肿的甲型溶血性链球菌会具有一些相同的特性。
