Kanamori Shuzo, Kusano Nobuchika, Shinzato Takashi, Saito Atsushi
Division of Internal Medicine, Department of Infectious Diseases Control, Graduate School and Faculty of Medicine, University of the Ryukyus, 207 Uehara, Nishihara, Okinawa 903-0215, Japan.
J Infect Chemother. 2004 Apr;10(2):105-9. doi: 10.1007/s10156-004-0305-7.
Study of the pathogenicity of encapsulated strains of the Streptococcus milleri group (SMG) was performed by examination of the ability to cause subcutaneous abscesses in mice and by phagocytosis and phagocytic killing of human polymorphonuclear neutrophils (PMNs) against the organisms. All 3 encapsulated isolates from patients with pneumonia or lung abscess induced abscesses in the mice; however, only 2 of 20 unencapsulated isolates from patients with lung abscess or thoracic empyema did so. The 3 encapsulated strains inhibited more phagocytosis and phagocytic killing of PMNs than the unencapsulated strains. In addition, encapsular material separated from Streptococcus constellatus RZYK001 also inhibited phagocytosis and phagocytic killing in proportion to increasing concentrations of the capsular material. These results suggest that capsular material produced by SMG might be a pathogenic factor.
通过检测米勒链球菌群（SMG）包膜菌株在小鼠体内引起皮下脓肿的能力以及人多形核中性粒细胞（PMN）对这些微生物的吞噬和吞噬杀伤作用，对其致病性进行了研究。来自肺炎或肺脓肿患者的所有3株包膜分离株均在小鼠体内诱导形成脓肿；然而，来自肺脓肿或胸腔积脓患者的20株非包膜分离株中只有2株能诱导形成脓肿。与非包膜菌株相比，3株包膜菌株对PMN的吞噬和吞噬杀伤作用的抑制作用更强。此外，从星座链球菌RZYK001分离出的包膜物质也随着包膜物质浓度的增加而抑制吞噬和吞噬杀伤作用。这些结果表明，SMG产生的包膜物质可能是一种致病因素。
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