Boag P R, Newton S E, Gasser R B
Victorian Institute of Animal Science, Attwood, Victoria 3049, Australia.
Adv Parasitol. 2001;50:153-98. doi: 10.1016/s0065-308x(01)50031-7.
In contrast to the free-living nematode Caenorhabditis elegans, surprisingly little is known about the molecular aspects of reproduction in parasitic helminths. Investigations into such aspects would provide an improved understanding of the fundamentals of sexual differentiation, development, maturation and behaviour, as well as sex-specific genes and their expression. Such knowledge could lead to new means of parasite control by interfering with or disrupting one or more of these processes, which is particularly important given the emerging problems with genetic resistance in parasitic nematodes against anthelmintic drugs. This chapter brings together some relevant information on the sexual biology of C. elegans, summarizes studies of gender-specific expression in selected parasitic helminths of socio-economic significance, describes advanced molecular techniques for the analysis of gender-specific genes, and indicates the prospects for genomic research on reproductive processes and the implications thereof for controlling parasitic helminths.
与自由生活的线虫秀丽隐杆线虫相比，令人惊讶的是，我们对寄生蠕虫繁殖的分子方面知之甚少。对这些方面的研究将有助于更好地理解性别分化、发育、成熟和行为的基本原理，以及性别特异性基因及其表达。这些知识可能会通过干扰或破坏这些过程中的一个或多个来带来新的寄生虫控制方法，鉴于寄生线虫对驱虫药物出现的遗传抗性问题，这一点尤为重要。本章汇集了一些关于秀丽隐杆线虫性生物学的相关信息，总结了对具有社会经济意义的选定寄生蠕虫中性别特异性表达的研究，描述了用于分析性别特异性基因的先进分子技术，并指出了生殖过程基因组研究的前景及其对控制寄生蠕虫的意义。
