Nisbet Alasdair J, Cottee Pauline, Gasser Robin B
Department of Veterinary Science, The University of Melbourne, 250 Princes Highway, Werribee, Victoria 3030, Australia.
Int J Parasitol. 2004 Feb;34(2):125-38. doi: 10.1016/j.ijpara.2003.09.012.
Molecular biological research on the development and reproduction of parasites is of major significance for many fundamental and applied areas of medical and veterinary parasitology. Together with knowledge of parasite biology and epidemiology, the application of molecular tools and technologies provides unique opportunities for elucidating developmental and reproductive processes in helminths. This article focuses specifically on recent progress in studying the molecular mechanisms of development, sexual differentiation and reproduction in parasitic nematodes of socio-economic importance and comparative analyses, where appropriate, with the free-living nematode Caenorhabditis elegans. It also describes the implications of such work for understanding reproduction, tissue migration, hypobiosis, signal transduction and host-parasite interactions at the molecular level, and for seeking new means of parasite intervention.
寄生虫发育与繁殖的分子生物学研究对于医学和兽医寄生虫学的许多基础及应用领域都具有重大意义。分子工具和技术与寄生虫生物学及流行病学知识相结合，为阐明蠕虫的发育和繁殖过程提供了独特的机会。本文特别关注在具有社会经济重要性的寄生线虫发育、性别分化和繁殖分子机制研究方面的最新进展，并在适当情况下与自由生活线虫秀丽隐杆线虫进行比较分析。文章还描述了此类研究工作在分子水平上对于理解繁殖、组织迁移、休眠、信号转导以及宿主 - 寄生虫相互作用的意义，以及在寻找寄生虫干预新方法方面的意义。
