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两种氯乙烯代谢产物，即氯环氧乙烷和2-氯乙醛，对中国仓鼠V79细胞的诱变作用。

Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.

作者信息

Huberman E, Bartsch H, Sachs L

出版信息

Int J Cancer. 1975 Oct 15;16(4):639-44. doi: 10.1002/ijc.2910160414.

DOI:10.1002/ijc.2910160414
PMID:1176210
Abstract

Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.

摘要

氯代环氧乙烷和2-氯乙醛是氯乙烯在哺乳动物体内的两种可能致癌的代谢产物，它们在体外对中国仓鼠V79细胞中8-氮杂鸟嘌呤和哇巴因抗性突变体的诱导呈剂量依赖性。大鼠和人体尿液中的氯乙烯代谢产物2-氯乙醇或一氯乙酸的浓度高达前者的一百倍时却没有活性。

相似文献

1
Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.两种氯乙烯代谢产物，即氯环氧乙烷和2-氯乙醛，对中国仓鼠V79细胞的诱变作用。
Int J Cancer. 1975 Oct 15;16(4):639-44. doi: 10.1002/ijc.2910160414.
2
The mutagenicity of chloroethylene oxide, chloroacetaldehyde, 2-chloroethanol and chloroacetic acid, conceivable metabolites of vinyl chloride.环氧氯乙烷、氯乙醛、2-氯乙醇和氯乙酸（氯乙烯可能的代谢产物）的致突变性。
Chem Biol Interact. 1976 Mar;12(3-4):251-63. doi: 10.1016/0009-2797(76)90041-7.
3
Induction of gene mutations and gene conversions by vinyl chloride metabolites in yeast.氯乙烯代谢产物在酵母中诱导基因突变和基因转换。
Cancer Res. 1977 Jan;37(1):253-7.
4
Mutagenicity of vinyl chloride, vinylidene chloride and chloroprene in V79 Chinese hamster cells.氯乙烯、偏二氯乙烯和氯丁二烯对V79中国仓鼠细胞的致突变性。
Mutat Res. 1979 Jun;67(2):173-82. doi: 10.1016/0165-1218(79)90129-0.
5
Vinyl chloride mutagenicity via the metabolites chlorooxirane and chloroacetaldehyde monomer hydrate.氯乙烯通过代谢产物氯环氧乙烷和氯乙醛单体水合物产生的致突变性。
Biochim Biophys Acta. 1976 Sep 6;442(3):405-19. doi: 10.1016/0005-2787(76)90314-2.
6
Mutagenicity and metabolism of vinyl chloride and related compounds.氯乙烯及相关化合物的致突变性与代谢
Environ Health Perspect. 1976 Oct;17:193-8. doi: 10.1289/ehp.7617193.
7
Mutagenicity of vinyl chloride, chloroethyleneoxide, chloroacetaldehyde and chloroethanol.氯乙烯、氯代环氧乙烷、氯乙醛和氯乙醇的致突变性。
Biochem Biophys Res Commun. 1975 Mar 17;63(2):363-70. doi: 10.1016/0006-291x(75)90697-x.
8
The effect of vinyl chloride monomer, chloroethylene oxide and chloracetaldehyde on DNA synthesis in regenerating rat liver.
Chem Biol Interact. 1977 May;17(2):239-47. doi: 10.1016/0009-2797(77)90088-6.
9
Interactions of vinyl chloride with rat-liver DNA in vivo.氯乙烯与大鼠肝脏DNA在体内的相互作用。
Chem Biol Interact. 1978 Sep;22(2-3):211-24. doi: 10.1016/0009-2797(78)90126-6.
10
Mutagenicity of chloroacetaldehyde, a possible metabolic product of 1,2-dichloroethane (ethylene dichloride), chloroethanol (ethylene chlorohydrin), vinyl chloride, and cyclophosphamide.氯乙醛的致突变性，氯乙醛是1,2 - 二氯乙烷（二氯化乙烯）、氯乙醇（氯乙醇）、氯乙烯和环磷酰胺的一种可能代谢产物。
Proc Natl Acad Sci U S A. 1975 Aug;72(8):3190-3. doi: 10.1073/pnas.72.8.3190.

引用本文的文献

1
Development and application of an LC-MS/MS method for the detection of the vinyl chloride-induced DNA adduct N(2),3-ethenoguanine in tissues of adult and weanling rats following exposure to [(13)C(2)]-VC.建立和应用 LC-MS/MS 方法检测[(13)C(2)]-VC 染毒成年和新生大鼠组织中氯乙烯诱导的 DNA 加合物 N(2),3-乙烯鸟嘌呤
Chem Res Toxicol. 2010 Sep 20;23(9):1485-91. doi: 10.1021/tx1001767.
2
Malignant tumors after chronic exposure to vinyl chloride.长期接触氯乙烯后的恶性肿瘤。
J Cancer Res Clin Oncol. 1981;102(1):1-11. doi: 10.1007/BF00410529.
3
Studies on the miscoding properties of 1,N6-ethenoadenine and 3,N4-ethenocytosine, DNA reaction products of vinyl chloride metabolites, during in vitro DNA synthesis.
氯乙烯代谢产物的DNA反应产物1,N6-乙烯腺嘌呤和3,N4-乙烯胞嘧啶在体外DNA合成过程中的错编码特性研究。
Nucleic Acids Res. 1981 Jan 24;9(2):375-87. doi: 10.1093/nar/9.2.375.
4
The pathology of vinyl chloride exposed mice.氯乙烯暴露小鼠的病理学
Acta Vet Scand. 1976;17(3):328-42. doi: 10.1186/BF03547913.
5
Mutagenic and alkylating metabolites of halo-ethylenes, chlorobutadienes and dichlorobutenes produced by rodent or human liver tissues. Evidence for oxirane formation by P450-linked microsomal mono-oxygenases.啮齿动物或人类肝脏组织产生的卤代乙烯、氯丁二烯和二氯丁烯的诱变和烷基化代谢产物。细胞色素P450相关微粒体单加氧酶形成环氧乙烷的证据。
Arch Toxicol. 1979 Feb 23;41(4):249-77. doi: 10.1007/BF00296896.