两种氯乙烯代谢产物，即氯环氧乙烷和2-氯乙醛，对中国仓鼠V79细胞的诱变作用。
Mutation induction in Chinese hamster V79 cells by two vinyl chloride metabolites, chloroethylene oxide and 2-chloroacetaldehyde.
作者信息
Huberman E, Bartsch H, Sachs L
出版信息
Int J Cancer. 1975 Oct 15;16(4):639-44. doi: 10.1002/ijc.2910160414.
PMID:1176210
Abstract
Chloroethylene oxide and 2-chloroacetaldehyde, two possibly carcinogenic metabolities of vinyl chloride in mammals, caused a dose-dependent induction of 8-azaguanine- and ouabain-resistant mutants in Chinese hamster V79 cells in vitro. Up to one-hundred-fold higher concentrations of 2-chloroethanol or monochloroacetic acid, a urinary vinyl chloride metabolite in rats and man, were inactive.
摘要
氯代环氧乙烷和2-氯乙醛是氯乙烯在哺乳动物体内的两种可能致癌的代谢产物，它们在体外对中国仓鼠V79细胞中8-氮杂鸟嘌呤和哇巴因抗性突变体的诱导呈剂量依赖性。大鼠和人体尿液中的氯乙烯代谢产物2-氯乙醇或一氯乙酸的浓度高达前者的一百倍时却没有活性。
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