氯乙烯及相关化合物的致突变性与代谢
Mutagenicity and metabolism of vinyl chloride and related compounds.
作者信息
Bartsch H, Malaveille C, Barbin A, Bresil H, Tomatis L, Montesano R
出版信息
Environ Health Perspect. 1976 Oct;17:193-8. doi: 10.1289/ehp.7617193.
Abstract
The various adverse biological effects of vinyl chloride appear to be dependent upon the metabolic conversion of this compound into chemically reactive metabolites. The metabolism of vinyl chloride in mammals and in man, including the formation of monochloroacetic acid and some identified sulfur conjugates is reviewed. Hepatic microsomal mixed function oxidases from rats, mice, and humans were equally effective in transforming vinyl chloride into alkylating agents in vitro. Two of the enzyme reaction products, i.e., chloroethylene oxide and 2-chloroacetaldehyde, showed potent genetic activity in microorganisms and Chinese hamster V79 cells. The role of liver microsomal enzymes in the generation of electrophilic mutagenic vinyl chloride metabolites is discussed.
摘要
氯乙烯的各种不良生物学效应似乎取决于该化合物代谢转化为化学反应性代谢物的过程。本文综述了氯乙烯在哺乳动物和人类中的代谢情况，包括一氯乙酸的形成以及一些已确定的硫共轭物。大鼠、小鼠和人类的肝微粒体混合功能氧化酶在体外将氯乙烯转化为烷基化剂方面同样有效。两种酶反应产物，即氯环氧乙烷和2-氯乙醛，在微生物和中国仓鼠V79细胞中显示出强大的遗传活性。本文还讨论了肝微粒体酶在亲电诱变氯乙烯代谢物生成中的作用。
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本文引用的文献
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Carcinogenicity of halo-ethers. II. Structure-activity relationships of analogs of bis(chloromethyl)ether.卤代醚的致癌性。II. 双（氯甲基）醚类似物的构效关系。
J Natl Cancer Inst. 1972 May;48(5):1431-9.
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Carcinogens are mutagens: a simple test system combining liver homogenates for activation and bacteria for detection.致癌物是诱变剂：一种将用于活化的肝脏匀浆和用于检测的细菌相结合的简单测试系统。
Proc Natl Acad Sci U S A. 1973 Aug;70(8):2281-5. doi: 10.1073/pnas.70.8.2281.
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Fate of (14C)vinyl chloride after single oral administration in rats.大鼠单次口服给予（14C）氯乙烯后的命运。
Toxicol Appl Pharmacol. 1976 May;36(2):339-52. doi: 10.1016/0041-008x(76)90013-2.
4
The biological fate in rats of vinyl chloride in relation to its oncogenicity.氯乙烯在大鼠体内的生物学归宿及其致癌性
Chem Biol Interact. 1975 Dec;11(6):545-62. doi: 10.1016/0009-2797(75)90030-7.
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Tissue-mediated mutagenicity of vinylidene chloride and 2-chlorobutadiene in Salmonella typhimurium.
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10
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