Mintz J, O'Brien C P, O'Hare K, Goldschmidt J
Int J Addict. 1975;10(5):815-24. doi: 10.3109/10826087509027340.
Twenty-four methadone maintenance patients were assigned to (1) decreasing dose (N = 12) or (2) continued methadone maintenance (N = 12), matching for dose, initial complaint levels, and counselor. After 14 weeks most patients in both groups had terminated from the study. Detoxifying patients usually terminated by obtaining a dose increase or dropping out; maintenance patients usually terminated for external reasons. Prior to terminating, detoxifying patients reported increased withdrawal complaints but no awareness doses had decreased. Termination was not directly related to dose level or percentage decrease. In both groups, terminators were likely to have been high in complaints during the baseline period.
24名美沙酮维持治疗患者被分为两组：(1) 减量组（N = 12）或 (2) 继续美沙酮维持治疗组（N = 12），两组在剂量、初始主诉水平和咨询员方面进行匹配。14周后，两组中的大多数患者都退出了研究。进行戒毒的患者通常通过增加剂量或退出治疗来终止研究；维持治疗的患者通常因外部原因终止治疗。在终止治疗前，进行戒毒的患者报告戒断症状增加，但未意识到剂量已减少。终止治疗与剂量水平或剂量减少百分比没有直接关系。在两组中，退出者在基线期的主诉可能较多。
