Soubiron L, Hantson P, Michaux I, Lambert M, Mahieu P, Pringot J
Department of Intensive Care, Cliniques Universitaires St-Luc, Brussels, Belgium.
Eur J Emerg Med. 2000 Dec;7(4):305-7. doi: 10.1097/00063110-200012000-00011.
Superwarfarins have progressively replaced warfarin as rodenticides as they are more potent and have a longer anticoagulant activity. Human exposure may be complicated by spontaneous haemorrhage in various sites. We report the case of a 51-year-old woman who was admitted with spontaneous haemoperitoneum and intramural haematoma along the small intestine. After the evidence of a deficit of vitamin K1-dependent clotting factors (II, VII, IX, X), the patient admitted that she was chronically ingesting difenacoum. She was successfully treated with fresh frozen plasma and vitamin K1. Follow-up was not accepted.
由于其更强效且具有更长的抗凝活性，超级华法林已逐渐取代华法林成为灭鼠剂。人体接触超级华法林可能会因各个部位的自发性出血而变得复杂。我们报告了一例51岁女性患者，她因自发性腹腔积血和小肠壁内血肿入院。在发现维生素K1依赖的凝血因子（II、VII、IX、X）缺乏的证据后，患者承认她长期摄入敌鼠钠。她通过输注新鲜冷冻血浆和维生素K1得到成功治疗。患者未接受随访。
