Morgan B W, Tomaszewski C, Rotker I
Department of Emergency Medicine, Carolinas Poison Center, Carolinas Medical Center, Charlotte, NC, USA.
Am J Emerg Med. 1996 Nov;14(7):656-9. doi: 10.1016/S0735-6757(96)90082-0.
Brodifacoum is a 4-hydroxycoumarin derivative that is commonly used as a rodenticide. Human exposures have produced severe coagulopathies resulting in hematuria, gastrointestinal bleeding, intracranial hemorrhage, and death. This is the first report of spontaneous hemoperitoneum secondary to brodifacoum ingestion. The patient was successfully managed with fresh frozen plasma, packed red blood cells, and vitamin K1. No surgical intervention was performed. The patient required ongoing daily vitamin K1 therapy for longer than 6 months.
溴敌隆是一种4-羟基香豆素衍生物，常用作灭鼠剂。人体接触后会引发严重的凝血障碍，导致血尿、胃肠道出血、颅内出血及死亡。这是首例因摄入溴敌隆继发自发性血腹的报告。患者通过输注新鲜冰冻血浆、浓缩红细胞及维生素K1成功得到救治。未进行手术干预。患者需要持续每日接受维生素K1治疗超过6个月。
