[慢性心力衰竭中的肿瘤坏死因子α。临床表现及治疗可能性]
[Tumor necrosis factor alpha in chronic heart failure. Clinical manifestation and therapeutic possibilities].
作者信息
Genth-Zotz S, Bolger A P, Anker S D
机构信息
National Heart & Lung Institute, Imperial College School of Medicine, London, UK.
出版信息
Herz. 2001 Nov;26(7):437-46. doi: 10.1007/pl00002046.
BACKGROUND
Chronic heart failure (CHF) may be seen as a multi-system disorder with its origin in the heart but including many extracardiac manifestations. Immunological abnormalities are recognized in this context, in particular, changes in the expression of mediators of the innate immune response.
IMPORTANCE OF TNF
Higher levels of the pro-inflammatory cytokine tumor necrosis factor-alpha (TNF) are found in the circulation and in the myocardium of patients with chronic heart failure than in controls. TNF has been implicated in a number of pathophysiological processes that are thought to be important to the progression of chronic heart failure. Therapies directed against this cytokine might therefore represent a novel approach to heart failure management.
背景
慢性心力衰竭（CHF）可被视为一种多系统疾病，其起源于心脏，但包括许多心外表现。在这种情况下，免疫异常是公认的，特别是先天性免疫反应介质表达的变化。
肿瘤坏死因子的重要性
与对照组相比，在慢性心力衰竭患者的循环系统和心肌中发现促炎细胞因子肿瘤坏死因子-α（TNF）水平更高。TNF参与了许多被认为对慢性心力衰竭进展很重要的病理生理过程。因此，针对这种细胞因子的治疗可能代表了一种治疗心力衰竭的新方法。
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