Updyke B V
J Comp Neurol. 1975 Oct 15;163(4):377-95. doi: 10.1002/cne.901630402.
The projection of cortical areas 17, 18, and 19 onto the laminar part of the dorsal lateral geniculate nucleus was investigated with degeneration methods and with the autoradiographic axon tracing method. In agreement with previous accounts, degenerating cortical axons stained by the Nauta method were restricted to laminae A, A1, C and to the interlaminar zones. In contrast, adjacent sections stained with the Fink-Heimer method showed fine dust like degeneration throughout all of the laminae of the nucleus. Comparisons of Fink-Heimer degeneration resulting from lesions of area 17 with that resulting from lesions of areas 18 and 19 further suggested that the area ) projection is heavier and more uniform than the projections from areas 18 and 19. Autoradiographic tracing of axons after intracortical injections of 3H-proline provided detailed demonstrations of the cortical projection patterns that confirmed the Fink-Heimer results. Following restricted injections of areas 17 or 18 the termination zones in the dorsal lateral geniculate nucleus consisted of columns of labeled tissue oriented perpendicular to the laminae of the nucleus. Area 17 was found to project heavily and uniformly throughout all of the laminae of the nucleus. The projection from area 18 also extended throughout all of the laminae of the nucleus, but was sparser and less uniformly distributed than that from area 17. Projections from area 18 distributed more heavily to the interlaminar zones and to lamina C than to laminae A, A1 C1, C2 or C3. A projection from area 19 to laminae C1, C2 and C3 was also demonstrated autoradiographically.
运用变性法和放射自显影轴突追踪法，对皮质17区、18区和19区投射到背外侧膝状核板层部分的情况进行了研究。与先前的报道一致，用瑙塔法染色的变性皮质轴突局限于A层、A1层、C层及层间区。相反，用芬克 - 海默法染色的相邻切片显示，整个核的所有板层都有细微的粉尘样变性。将17区损伤所致的芬克 - 海默变性与18区和19区损伤所致的变性进行比较，进一步表明17区的投射比18区和19区的投射更密集且更均匀。皮质内注射³H - 脯氨酸后对轴突进行放射自显影追踪，详细展示了皮质投射模式，证实了芬克 - 海默法的结果。在对17区或18区进行局限性注射后，背外侧膝状核中的终末区由垂直于核板层排列的标记组织柱组成。发现17区在核的所有板层上都有大量且均匀的投射。18区的投射也延伸至核的所有板层，但比17区的投射更稀疏且分布更不均匀。18区的投射在层间区和C层的分布比在A层、A1层、C1层、C2层或C3层更密集。放射自显影也证实了19区向C1层、C2层和C3层有投射。
