Kiho T, Kochi M, Usui S, Hirano K, Aizawa K, Inakuma T
Gifu Pharmaceutical University, Japan.
Biol Pharm Bull. 2001 Dec;24(12):1400-3. doi: 10.1248/bpb.24.1400.
Continuous oral administration of the acidic polysaccharide (TAP) solution (0.5 g/l) and the TAP-H (degradation products of TAP) solution (1.5 g/l) instead of water for 10 weeks were found to depress plasma glucose increases in diabetes using genetically non-insulin-dependent diabetic model (KK-Ay) mice. TAP and TAP-H significantly lowered levels of insulin, total-cholesterol and triglyceride in the blood of the mice. In excretion to feces, TAP and TAP-H significantly increased the total bile acid, while the cholesterol content of both groups was less than that of the control. Furthermore, TAP and TAP-H significantly decreased the plasma lipoperoxide level. The study shows that TAP and TAP-H have an antidiabetic effect on diabetes model mice.
在使用遗传性非胰岛素依赖型糖尿病模型（KK-Ay）小鼠的实验中，连续10周口服酸性多糖（TAP）溶液（0.5克/升）和TAP-H（TAP的降解产物）溶液（1.5克/升）以替代饮水，结果发现可抑制糖尿病小鼠的血糖升高。TAP和TAP-H显著降低了小鼠血液中的胰岛素、总胆固醇和甘油三酯水平。在粪便排泄方面，TAP和TAP-H显著增加了总胆汁酸，而两组的胆固醇含量均低于对照组。此外，TAP和TAP-H显著降低了血浆脂质过氧化物水平。该研究表明，TAP和TAP-H对糖尿病模型小鼠具有抗糖尿病作用。
