Dubey Sushil K, Chaturvedi Vivek K, Mishra Divya, Bajpeyee Anand, Tiwari Aprajita, Singh M P
1Centre of Biotechnology, Institute of Interdisciplinary Studies (IIDS), University of Allahabad, Prayagraj, 211002 India.
2Centre of Bioinformatics, Institute of Interdisciplinary Studies (IIDS), University of Allahabad, Prayagraj, 211002 India.
3 Biotech. 2019 Dec;9(12):450. doi: 10.1007/s13205-019-1982-3. Epub 2019 Nov 14.
Diabetes and obesity are the most frequently found disease worldwide. Several factors are responsible for obesity, i.e., imbalance in energy expenditure, environmental factors, feeding habit, lifestyle, etc., which can also be responsible for type 2 diabetes mellitus. There are several synthetic drugs available to combat these diseases which have some side effects on sufferers. Therefore, people are shifting towards inexpensive, effective, widely available natural and herbal medicines. Edible mushrooms, which have been used from ancient time to cure these diseases, contain anti-oxidant, fibers, triterpenoids, alkaloid, and other phytochemicals. Comatin, β-glucan, Tremellastin, and Lentinan KS-2 are active chemicals of mushrooms which show great effect on diabetes mellitus and obesity by modulating either cellular function or biochemical pathways. Here, in this review, we have discussed the potential role of edible mushrooms and its biochemicals in control of diabetes and obesity. Using Bioinformatics, we can find the specific targets of theses biochemicals, so that these can be more effective.
糖尿病和肥胖是全球最常见的疾病。肥胖由多种因素引起，即能量消耗失衡、环境因素、饮食习惯、生活方式等，这些因素也可能导致2型糖尿病。有几种合成药物可用于对抗这些疾病，但对患者有一些副作用。因此，人们正转向价格低廉、有效、广泛可得的天然和草药。食用蘑菇自古以来就被用于治疗这些疾病，它含有抗氧化剂、纤维、三萜类化合物、生物碱和其他植物化学物质。香菇嘌呤、β-葡聚糖、银耳多糖和香菇多糖KS-2是蘑菇的活性化学物质，它们通过调节细胞功能或生化途径对糖尿病和肥胖症有显著疗效。在此综述中，我们讨论了食用蘑菇及其生化物质在控制糖尿病和肥胖症方面的潜在作用。利用生物信息学，我们可以找到这些生化物质的特定靶点，从而使其更有效。
