熊果酸对KK-Ay糖尿病小鼠的抗糖尿病作用。
Antidiabetic effects of corosolic acid in KK-Ay diabetic mice.
作者信息
Miura Toshihiro, Ueda Naoya, Yamada Koutaro, Fukushima Mitsuo, Ishida Torao, Kaneko Tetsuo, Matsuyama Futoshi, Seino Yutaka
机构信息
Department of Clinical Nutrition, Suzuka University of Medical Science, Mie, Japan.
出版信息
Biol Pharm Bull. 2006 Mar;29(3):585-7. doi: 10.1248/bpb.29.585.
The antidiabetic effects of corosolic acid (CA) were investigated in KK-Ay mice, an animal model of type 2 diabetes. CA (2 mg/kg body weight) reduced the blood glucose levels of KK-Ay mice 4 h after a single oral dose. CA (2 mg/kg) reduced the blood glucose levels in KK-Ay mice 2 weeks after a single oral dose and also significantly lowered plasma insulin levels were in KK-Ay mice under similar conditions. CA-treated KK-Ay mouse blood glucose significantly decreased in an insulin tolerance test. These results support the hypothesis that CA improves glucose metabolism by reducing insulin resistance. Therefore CA may be useful for the treatment of type 2 diabetes.
在2型糖尿病动物模型KK-Ay小鼠中研究了科罗索酸（CA）的抗糖尿病作用。单次口服剂量2mg/kg体重的CA可降低KK-Ay小鼠4小时后的血糖水平。单次口服剂量2mg/kg的CA可降低KK-Ay小鼠单次口服给药2周后的血糖水平，并且在类似条件下也显著降低了KK-Ay小鼠的血浆胰岛素水平。在胰岛素耐受性试验中，经CA处理的KK-Ay小鼠血糖显著降低。这些结果支持了CA通过降低胰岛素抵抗来改善葡萄糖代谢的假说。因此，CA可能对2型糖尿病的治疗有用。
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