Osadchiĭ L I, Balueva T V, Sergeev I V
I. P. Pavlov Institute of Physiology, Russian Acad. Sci., St. Petersburg, 199034, Nab. Makarova, 6, Russia.
Ross Fiziol Zh Im I M Sechenova. 2001 Oct;87(10):1325-32.
A stepwise decrease in the blood pressure by means of sodium nitroprusside infusion led to progressing diminishing of mesatone pressor effects in anaesthetised rats. Cardiac output changes due to mesatone administration did not depend on the initial blood pressure. The latter being lower than physiological limits, a direct linear correlation occurred between pressor responses and shifts of general peripheral resistance, on one hand, and the degree of the blood pressure initial drop, on the other hand. The constrictor responses under study are discussed in respect to their dependence on initial tone of arterial vessels.
通过输注硝普钠逐步降低血压，导致麻醉大鼠中去甲肾上腺素升压作用逐渐减弱。去甲肾上腺素给药引起的心输出量变化不依赖于初始血压。当后者低于生理限度时，一方面升压反应与总外周阻力变化之间，另一方面与血压初始下降程度之间存在直接线性关系。根据对动脉血管初始张力的依赖性，对所研究的收缩反应进行了讨论。
