Osadchii L I, Balueva T V, Sergeev I V
Laboratory of Blood Circulation Physiology, I. P. Pavlov Institute of Physiology, Russian Academy of Sciences, St. Petersburg.
Bull Exp Biol Med. 2003 Jun;135(6):530-3. doi: 10.1023/a:1025456730318.
Systemic vasodilation produced by sodium nitroprusside in various concentrations and accompanied by a decrease in baseline blood pressure was followed by progressive reduction in pressor responses to alpha-adrenoceptor agonist phenylephrine (mesatone) in rats. In a blood pressure range of below the physiological level (80-100 mm Hg), a positive linear correlation was revealed between the decrease in baseline blood pressure and pressor effect of phenylephrine.
硝普钠在不同浓度下可引起大鼠全身血管舒张，并伴有基础血压下降，随后对α-肾上腺素能受体激动剂去氧肾上腺素（美速克新命）的升压反应逐渐降低。在低于生理水平的血压范围（80 - 100 mmHg）内，基础血压的降低与去氧肾上腺素的升压作用之间呈正线性相关。
