Smith G K, Mayhew P D, Kapatkin A S, McKelvie P J, Shofer F S, Gregor T P
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104, USA.
J Am Vet Med Assoc. 2001 Dec 15;219(12):1719-24. doi: 10.2460/javma.2001.219.1719.
To determine whether age, breed, sex, weight, or distraction index (DI) was associated with the risk that dogs of 4 common breeds (German Shepherd Dog, Golden Retriever, Labrador Retriever, Rottweiler) would have radiographic evidence of degenerative joint disease (DJD) associated with hip dysplasia.
Cross-sectional prevalence study.
15,742 dogs.
Hips of dogs were evaluated radiographically by use of the ventrodorsal hip-extended view, the compression v ew, and the distraction view. The ventrodorsal hip-extended view was examined to determine whether dogs had DJD. For each breed, a multiple logistic regression model incorporating age, sex, weight, and DI was created. For each breed, disease-susceptibility curves were produced, using all dogs, regardless of age, and dogs grouped on the basis of age.
Weight and DI were significant risk factors for DJD in all breeds. For German Shepherd Dogs, the risk of having DJD was 4.95 times the risk for dogs of the other 3 breeds combined. In all breeds, the probability of having DJD increased with age.
Results indicated that the probability of having hip DJD increased with hip joint laxity as measured by use of DI. This association was breed-specific, indicating that breed-specific information on disease susceptibility should be incorporated when making breeding decisions and when deciding on possible surgical treatment of hip dysplasia.
确定年龄、品种、性别、体重或牵引指数(DI)是否与4种常见品种(德国牧羊犬、金毛寻回犬、拉布拉多寻回犬、罗威纳犬)的犬只出现与髋关节发育不良相关的退行性关节病(DJD)的影像学证据的风险有关。
横断面患病率研究。
15742只犬。
通过腹背位髋关节伸展位、压迫位和牵引位X线片对犬的髋关节进行评估。检查腹背位髋关节伸展位X线片以确定犬是否患有DJD。对于每个品种,建立一个纳入年龄、性别、体重和DI的多元逻辑回归模型。对于每个品种,使用所有犬只(无论年龄)以及按年龄分组的犬只绘制疾病易感性曲线。
体重和DI是所有品种DJD的显著风险因素。对于德国牧羊犬,患DJD的风险是其他3个品种犬只综合风险的4.95倍。在所有品种中,患DJD的概率随年龄增加。
结果表明,通过DI测量,髋关节DJD的概率随髋关节松弛度增加。这种关联具有品种特异性,表明在做出繁殖决策和决定髋关节发育不良的可能手术治疗时,应纳入特定品种的疾病易感性信息。