Runge J J, Kelly S P, Gregor T P, Kotwal S, Smith G K
Department of Clinical Studies, Matthew J. Ryan Veterinary Hospital at the University of Pennsylvania, Philadelphia, PA, USA.
J Small Anim Pract. 2010 May;51(5):264-9. doi: 10.1111/j.1748-5827.2010.00937.x.
To determine if age, breed, gender, weight or distraction index (DI) influenced the risk of radiographic osteoarthritis (OA) of canine hip dysplasia (CHD) in four common dog breeds; the American bulldog, Bernese mountain dog, Newfoundland and standard poodle.
This was a cross sectional prevalence study with 4349 dogs. Canine hips were evaluated using 3 radiographic projections: the hip-extended view, the compression view and the distraction view. The hip-extended view was examined for the presence of OA. The PennHIP distraction view was utilized to calculate the DI. For all breeds, a multiple logistic regression model incorporating age, weight, gender, and DI was created. For each breed, disease-susceptibility curves grouping dogs on the basis of age were constructed. Receiver-operating characteristic (ROC) curves were developed for each breed regardless of age.
For all breeds, DI was the most significant risk factor for the development of OA associated with CHD. Weight and age were also significant risk factors in all four breeds, but gender was not.
Results from this study support previous findings, that irrespective of breed, the probability of radiographic OA increases with hip joint laxity as measured by the DI. Breed-specific differences in this relationship, however, warrant investigation of all breeds affected by CHD to determine inherent dependency of hip OA on joint laxity. Such findings guide veterinarians in helping dog breeders to make evidence-based breeding decisions and in informing dog owners to implement preventative treatments for CHD for dogs found to be at risk.
确定年龄、品种、性别、体重或牵张指数（DI）是否会影响四种常见犬种（美国斗牛犬、伯恩山犬、纽芬兰犬和标准贵宾犬）患髋关节发育不良（CHD）的放射性骨关节炎（OA）风险。
这是一项对4349只犬进行的横断面患病率研究。使用三种放射影像投照评估犬的髋关节：髋关节伸展位、压迫位和牵张位。检查髋关节伸展位是否存在OA。利用宾夕法尼亚大学髋关节牵张位影像计算DI。针对所有犬种，建立了一个纳入年龄、体重、性别和DI的多元逻辑回归模型。针对每个犬种，构建了根据年龄对犬进行分组的疾病易感性曲线。无论年龄如何，为每个犬种绘制了受试者操作特征（ROC）曲线。
对于所有犬种，DI是与CHD相关的OA发生的最显著风险因素。体重和年龄在所有四个犬种中也是显著风险因素，但性别不是。
本研究结果支持先前的发现，即无论品种如何，通过DI测量的髋关节松弛度增加时，放射性OA的发生概率也会增加。然而，这种关系中特定品种的差异需要对所有受CHD影响的犬种进行调查，以确定髋关节OA对关节松弛度的内在依赖性。这些发现指导兽医帮助犬类繁殖者做出基于证据的繁殖决策，并告知犬主对发现有风险的犬实施CHD的预防性治疗。
