Smith G K, Popovitch C A, Gregor T P, Shofer F S
Department of Clinical Studies, School of Veterinary Medicine, University of Pennsylvania, Philadelphia 19104-6010, USA.
J Am Vet Med Assoc. 1995 Mar 1;206(5):642-7.
Passive coxofemoral joint laxity of dogs, as quantitated by a distraction-stress radiographic method, may have important prognostic value in determining susceptibility to hip dysplasia. Data from 151 dogs, representing 13 breeds, were included in a logistic regression model to evaluate the contribution of factors such as age, breed, weight, sex, distraction index, and Norberg angle to the risk of developing degenerative joint disease (DJD) of the coxofemoral joint. Of the factors studied, the amount of passive hip laxity, as quantitated by the distraction index, was the most significant (P < 0.0001) determinant of the risk to develop DJD of the coxofemoral joint. In the longitudinal and cross-sectional components of the study, distraction index was a significant (P < 0.001) risk factor for DJD, irrespective of age at evaluation (4, 12, or 24 months). The strength of the hip laxity:DJD correlation increased with the age of dog. In contrast, the Norberg angle, a measure of hip laxity on the standard hip-extended radiograph, was not found to be a significant risk factor for DJD, either in the longitudinal or cross-sectional analyses. Breed-specific probability curves of DJD susceptibility indicated that German Shepherd Dogs had a significantly (P < 0.05) greater risk of developing DJD than did the pool of non-German Shepherd Dogs. The information derived from this statistical model will help to scientifically characterize the role of passive hip laxity as a component in the pathogenesis of DJD of the coxofemoral joint.
通过牵引 - 应力放射照相法测定的犬被动性股髋关节松弛度，在确定髋关节发育不良易感性方面可能具有重要的预后价值。来自13个品种的151只犬的数据被纳入逻辑回归模型，以评估年龄、品种、体重、性别、牵引指数和诺伯格角等因素对股髋关节发生退行性关节病（DJD）风险的影响。在所研究的因素中，由牵引指数定量的被动性髋关节松弛量是股髋关节发生DJD风险的最显著（P < 0.0001）决定因素。在研究的纵向和横断面部分，无论评估时的年龄（4、12或24个月）如何，牵引指数都是DJD的显著（P < 0.001）风险因素。髋关节松弛度与DJD的相关性强度随犬的年龄增加而增加。相比之下，在纵向或横断面分析中，标准髋关节伸展位X线片上测量髋关节松弛度的诺伯格角均未被发现是DJD的显著风险因素。DJD易感性的品种特异性概率曲线表明，德国牧羊犬发生DJD的风险显著（P < 0.05）高于非德国牧羊犬群体。从该统计模型得出的信息将有助于科学地描述被动性髋关节松弛在股髋关节DJD发病机制中的作用。
