Liu H, Liu T, Ren H
Department of Pathology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100730, China.
Zhonghua Bing Li Xue Za Zhi. 2001 Oct;30(5):325-7.
To study the clinical and pathological characteristics of diffuse panbronchiolitis (DPB).
Clinical history of six cases of DPB and their pathological slides were studied and analyzed.
Diffuse panbronchiolitis was characterized by chronic recurrent nasosinusitis and pulmonary infection and respiratory bronchiolitis. Pathologically, all layers of the respiratory bronchiole walls were involved. Prominent chronic inflammation with lymphocytes, plasma cells and histiocytes infiltration was noted in all cases. In the lumens of the bronchioles, PMN or mucus could be identified. The chronic inflammatory cell infiltration also contained numerous foamy macrophages within the walls of the small bronchioles and in the stroma of the lung as well. Among the 6 cases of DPB, two cases were associated with thymoma.
DPB is a distinct clinicopathological entity. Open lung biopsy or thorocoscopic biopsy is necessary for the correct diagnosis of clinical atypical DPB cases.
研究弥漫性泛细支气管炎（DPB）的临床和病理特征。
对6例DPB患者的临床病史及其病理切片进行研究分析。
弥漫性泛细支气管炎的特征为慢性复发性鼻窦炎、肺部感染及呼吸性细支气管炎。病理上，呼吸性细支气管壁各层均受累。所有病例均可见显著的慢性炎症，伴有淋巴细胞、浆细胞和组织细胞浸润。在细支气管腔内，可发现中性粒细胞或黏液。慢性炎性细胞浸润在小支气管壁及肺间质内也包含大量泡沫状巨噬细胞。6例DPB患者中，2例与胸腺瘤相关。
DPB是一种独特的临床病理实体。对于临床非典型DPB病例，开胸肺活检或胸腔镜活检对于正确诊断是必要的。
