Buzzi G, Mostacci B, Sancisi E, Cirignotta F
Department of Neurology, S. Orsola-Malpighi Hospital, University of Bologna, Italy.
Funct Neurol. 2001 Jul-Sep;16(3):245-52.
Neuronal potassium conductance has been shown to influence the sleep-wake cycle and REM sleep homeostasis. The periodic paralyses (PP) are characterized by episodes of muscular weakness associated with changes in serum potassium levels and, therefore, with possible alterations in extracellular neuronal potassium conductance. We submitted a sleep questionnaire to the members of Periodic Paralysis International Listserv, an on-line support and information group for subjects with PP. Three control groups were made up of patients with untreated depression, patients with depression under treatment and healthy subjects. Both subjects with PP and those with untreated depression had a higher frequency of self-reported insufficient sleep quality and a higher number of nocturnal awakenings than patients with depression under treatment and healthy controls. PP subjects had more self-reported daytime sleepiness, sleep-related hallucinations and nightmares/abnormal dreams than the other three groups. Patients affected by PP may have disrupted sleep architecture and homeostasis. In particular, we suggest that the stereotypical abnormal dreams reported by several patients may reflect oneiric elaboration of nocturnal episodes of flaccid paralysis, while the increased frequency of sleep-related hallucinations may be due to enhanced REM sleep expression associated with alterations of neuronal potassium conductance.
神经元钾电导已被证明会影响睡眠-觉醒周期和快速眼动睡眠稳态。周期性麻痹（PP）的特征是与血清钾水平变化相关的肌肉无力发作，因此可能与细胞外神经元钾电导的改变有关。我们向周期性麻痹国际邮件列表的成员发放了一份睡眠问卷，该列表是一个为PP患者提供在线支持和信息的组织。三个对照组分别由未治疗的抑郁症患者、正在接受治疗的抑郁症患者和健康受试者组成。与正在接受治疗的抑郁症患者和健康对照组相比，PP患者和未治疗的抑郁症患者自我报告的睡眠质量不足频率更高，夜间觉醒次数更多。PP患者自我报告的白天嗜睡、与睡眠相关的幻觉和噩梦/异常梦境比其他三组更多。受PP影响的患者可能存在睡眠结构和稳态紊乱。特别是，我们认为一些患者报告的刻板异常梦境可能反映了夜间弛缓性麻痹发作的梦境加工，而与睡眠相关幻觉频率的增加可能是由于与神经元钾电导改变相关的快速眼动睡眠表达增强。
