Vignatelli Luca, Bisulli Francesca, Naldi Ilaria, Ferioli Simona, Pittau Francesca, Provini Federica, Plazzi Giuseppe, Vetrugno Roberto, Montagna Pasquale, Tinuper Paolo
Dipartimento di Scienze Neurologiche, Università di Bologna, Bologna, Italy.
Epilepsia. 2006;47 Suppl 5:73-7. doi: 10.1111/j.1528-1167.2006.00882.x.
Nocturnal frontal lobe epilepsy (NFLE) may be associated with sleep fragmentation and reduced sleep efficiency. Daytime sleepiness and disturbed sleep quality have been reported in some patients. We investigated the occurrence of daytime sleepiness-related symptoms and subjective sleep quality in patients with NFLE in comparison with matched controls.
Patients with NFLE at a single epilepsy center and matched controls randomly selected from the general population self-administered questionnaires on daytime sleepiness-related symptoms and subjective sleep quality [Epworth sleepiness scale (ESS), Bologna questionnaire on sleepiness-related symptoms (BQS), Berlin questionnaire].
Thirty-three patients with NFLE and 27 controls were enrolled. "Tiredness after awakening" and "spontaneous mid-sleep awakenings" were more frequent in NFLE patients than in controls (36.4% versus 11.1%, p = 0.04, and 50.0% versus 22.2%, p = 0.03). The frequency of excessive daytime sleepiness (EDS) did not differ between groups. Posthoc analysis showed that patients with a complaint of "midsleep awakenings" had higher ESS and BQS scores than those without (7.3 versus 4.3, p = 0.004, and 5.0 versus 2.2, p = 0.001, respectively) and more frequent "tiredness after awakening" (56.3% versus 18.8%, p = 0.03).
Patients with NFLE have no pathological level of EDS with respect to controls. However, daytime sleepiness-related symptoms could be more frequent in a subgroup of patients with subjective disturbed sleep quality, irrespective of the perceived frequency of seizures.
夜间额叶癫痫（NFLE）可能与睡眠片段化及睡眠效率降低有关。据报道，部分患者存在日间嗜睡及睡眠质量紊乱的情况。我们对NFLE患者与匹配的对照组进行比较，调查了与日间嗜睡相关症状及主观睡眠质量的发生情况。
来自单一癫痫中心的NFLE患者及从普通人群中随机选取的匹配对照组，自行填写关于日间嗜睡相关症状及主观睡眠质量的问卷[爱泼华嗜睡量表（ESS）、博洛尼亚嗜睡相关症状问卷（BQS）、柏林问卷]。
纳入33例NFLE患者及27例对照组。NFLE患者“觉醒后疲倦”及“睡眠中自发觉醒”的发生率高于对照组（分别为36.4%对11.1%，p = 0.04；50.0%对22.2%，p = 0.03）。两组间日间过度嗜睡（EDS）的发生率无差异。事后分析显示，主诉“睡眠中觉醒”的患者ESS及BQS评分高于无此主诉者（分别为7.3对4.3，p = 0.004；5.0对2.2，p = 0.001），且“觉醒后疲倦”更频繁（56.3%对18.8%，p = 0.03）。
相对于对照组，NFLE患者的EDS无病理水平。然而，无论癫痫发作的感知频率如何，在主观睡眠质量紊乱的患者亚组中，与日间嗜睡相关的症状可能更频繁。
