Musch B C, Papapetropoulos T A, McQueen D A, Hudgson P, Weightman D
J Neurol Sci. 1975 Oct;26(2):221-34. doi: 10.1016/0022-510x(75)90034-9.
A light- and electron-microscopic study of the small arterial vessels and capillaries in muscle from 20 patients with Duchenne muscular dystrophy failed to adduce any direct morphological evidence that the necrobiotic muscle lesions in this disease are produced by muscle ischaemia. However the electron-microscopic studies showed that the basement membrane width in 3 out of 4 cases of Duchenne dystrophy so studied was significantly less than that or normal control material. In further case of Duchenne dystrophy, selected for study because some vessels in the biopsy muscle were surrounded by small round cell infilitrates, the basement membrane width was significantly greater than that in the normal control material. In the single case of spinal muscular atrophy studied, the basement membrane width was also significantly less than the control measurements. The possible relationship of these observations to the "ischaemic" theory of the pathogenesis of muscular dystrophy is discussed.
对20例杜兴氏肌营养不良症患者肌肉中的小动脉血管和毛细血管进行的光镜和电镜研究，未能找到任何直接的形态学证据表明该疾病中的坏死性肌肉病变是由肌肉缺血引起的。然而，电镜研究显示，在所研究的4例杜兴氏肌营养不良症病例中，有3例的基底膜宽度明显小于正常对照材料。在另一例因活检肌肉中的一些血管被小圆细胞浸润而被选作研究对象的杜兴氏肌营养不良症病例中，基底膜宽度明显大于正常对照材料。在所研究的1例脊髓性肌萎缩症病例中，基底膜宽度也明显小于对照测量值。本文讨论了这些观察结果与肌营养不良症发病机制的“缺血”理论之间的可能关系。
