Matlashewski G
Department of Microbiology and Immunology, McGill University, Montreal, Quebec, Canada.
Med Microbiol Immunol. 2001 Nov;190(1-2):37-42. doi: 10.1007/s004300100076.
Leishmaniasis is among the most important infectious diseases of the developing world. With the advent of effective culture conditions for the various stages of the life cycle, together with state of the art biochemical, genomics, and reverse genetic approaches, it has been possible to identify virulence factors required for the infection process. Several of these virulence factors are discussed within including lipophosphoglygan, A2, cysteine proteinases, and gp63.
利什曼病是发展中世界最重要的传染病之一。随着利什曼原虫生命周期各阶段有效培养条件的出现，以及先进的生化、基因组学和反向遗传学方法的发展，现已能够确定感染过程所需的毒力因子。本文将讨论其中的几种毒力因子，包括脂磷壁酸聚糖、A2、半胱氨酸蛋白酶和gp63。
