Department of Medicine, The Research Institute of the McGill University Health Centre, Faculty of Medicine, McGill University, Montréal, Québec, Canada.
Microbes Infect. 2012 Dec;14(15):1377-89. doi: 10.1016/j.micinf.2012.05.014. Epub 2012 Jun 6.
Parasites of Leishmania genus have developed elegant strategies permitting them to evade the innate immune response upon their initial interaction with macrophages. Their capacity to dodge the induction of macrophages microbicidal functions was found to correlate with the alteration of several signalling pathways regulating those latter. In this review, the role of the Leishmania GP63 as a critical virulence factor influencing macrophage physiology will be discussed.
利什曼原虫属的寄生虫已经发展出了巧妙的策略，使它们在与巨噬细胞最初相互作用时能够逃避先天免疫反应。它们逃避诱导巨噬细胞杀菌功能的能力与调节这些功能的几种信号通路的改变有关。在这篇综述中，将讨论利什曼原虫 GP63 作为一个关键的毒力因子如何影响巨噬细胞的生理功能。
