Hashem F K, Al Homsi M, Mahasin Z Z, Gammas M A
Department of Surgery, King Faisal Specialist Hospital & Research Centre, Riyadh, Saudi Arabia.
J Otolaryngol. 2001 Dec;30(6):334-9. doi: 10.2310/7070.2001.19382.
The Medpor implant (Porex Surgical, College Park, GA) is a porous polyethylene that has been used safely in areas in the head and neck. Medpor allows the in-growth of capillaries and soft tissue and reduces the risk of infection and extrusion. This study was undertaken to evaluate the use of the Medpor implant in laryngotracheal reconstruction and to compare epithelialization of the trachea following two different methods at various intervals.
Eight beagles were divided into two groups. The first group underwent laryngotracheoplasty using the Medpor implant only, whereas the second group had the Medpor implant lined with a strap muscle flap. One animal from each group was sacrificed at 5-, 7-, 9-, and 12-month intervals. The degree of stenosis, inflammation, and epithelialization were compared.
The Medpor implant can safely be used to reconstruct the trachea in this animal model. There is less stenosis and better epithelialization when the Medpor implant is lined with a strap muscle flap.
The Medpor implant can safely be used in laryngotracheal reconstruction in beagles.
Medpor植入物（美国佐治亚州大学公园市Porex Surgical公司生产）是一种多孔聚乙烯材料，已在头颈部区域安全使用。Medpor能使毛细血管和软组织向内生长，并降低感染和挤出的风险。本研究旨在评估Medpor植入物在喉气管重建中的应用，并比较两种不同方法在不同时间间隔后气管的上皮化情况。
8只比格犬分为两组。第一组仅使用Medpor植入物进行喉气管成形术，而第二组的Medpor植入物内衬带状肌瓣。每组分别在5个月、7个月、9个月和12个月时处死1只动物。比较狭窄程度、炎症和上皮化情况。
在该动物模型中，Medpor植入物可安全用于重建气管。当Medpor植入物内衬带状肌瓣时，狭窄程度较轻，上皮化效果更好。
Medpor植入物可安全用于比格犬的喉气管重建。
