Gazzola L M, Saegesser F
J Surg Oncol. 1975;7(4):293-8. doi: 10.1002/jso.2930070405.
Twenty-seven patients who developed cancer of the stomach after undergoing gastric resection (GR), gastroenterostomy (GE), and vagotomy and pyloroplasty (VP) for benign gastric or duodenal ulcer are reported. The etiology and the pathogenesis of this type of cancer are discussed. Long-term exposure of the gastric mucosa to bile and duodenal and pancreatic secretion reflux seems to create a premalignant potential state. Symptoms and the diagnostic methods of radiologic series, cytology, and endoscopy are discussed. We suggest a curative operative approach and discuss the poor value of palliative procedures. We emphasize the necessity of determining the prognosis with exploratory laparotomy which establishes at the same time the certitude of the diagnosis.
报告了27例因良性胃或十二指肠溃疡接受胃切除术（GR）、胃肠吻合术（GE）以及迷走神经切断术和幽门成形术（VP）后发生胃癌的患者。讨论了这类癌症的病因和发病机制。胃黏膜长期暴露于胆汁以及十二指肠和胰腺分泌物反流似乎会造成一种癌前潜在状态。讨论了放射学系列检查、细胞学检查和内镜检查的症状及诊断方法。我们提出了一种根治性手术方法，并讨论了姑息性手术的低价值。我们强调通过剖腹探查术确定预后的必要性，剖腹探查术同时也能确定诊断的准确性。
