Bel Hadj Hmida Y, Tahri N, Sellami A, Yangui N, Jlidi R, Beyrouti M I, Krichen M S, Masmoudi H
Laboratoire d'Immunologie, CHU Habib Bourguiba Sfax.
Tunis Med. 2001 Aug-Sep;79(8-9):434-40.
In order to determine the sensitivity of CEA in the diagnosis of colo-rectal carcinoma, we studied a series of 48 patients with colo-rectal carcinoma (1992-1996). The sensitivity was at 52% with a reference value of 5 ng/ml and 68.7% for a reference value of 2.5 ng/ml. With a reference value of 5 ng/ml, the sensitivity of CEA was at 37% only for patients with colo-rectal carcinoma at Dukes B stage, 66.6% for patients at stage C and 75% for patients at stage D. The dosage of CEA was carried out with a sandwich immunoenzymatic technique in tube. There is no statistic significant correlation between the pre-operative rate of CEA and the localisation of the tumor and its histologic type; in contrast, it was significantly correlated with the ganglionnary metastasis. A significant relationship between the pre-operative rate of CEA and the Dukes stage was found for a reference value of 10 ng/ml but not for a reference value of 5 ng/ml. We calculated the specificity of the CEA for the cancers of colon and rectum which was at 76.98% with a reference value of 5 ng/ml and 86% with a reference value of 10 ng/ml.
为了确定癌胚抗原（CEA）在诊断结直肠癌中的敏感性，我们研究了1992年至1996年期间的48例结直肠癌患者。当参考值为5 ng/ml时，敏感性为52%；当参考值为2.5 ng/ml时，敏感性为68.7%。当参考值为5 ng/ml时，CEA对处于Dukes B期的结直肠癌患者的敏感性仅为37%，对C期患者为66.6%，对D期患者为75%。CEA的检测采用试管夹心免疫酶技术。术前CEA水平与肿瘤的位置及其组织学类型之间无统计学显著相关性；相反，它与淋巴结转移显著相关。当参考值为10 ng/ml时，术前CEA水平与Dukes分期之间存在显著关系，但当参考值为5 ng/ml时则不存在。我们计算了CEA对结肠癌和直肠癌的特异性，当参考值为5 ng/ml时为76.98%，当参考值为10 ng/ml时为86%。
