系统性红斑狼疮患者中Th1/Th2型细胞与疾病活动度的关系。
The relationship between Th1/Th2-type cells and disease activity in patients with systemic lupus erythematosus.
作者信息
Chen S, Hu D, Shi X, Shen N, Gu Y, Bao C
机构信息
Department of Rheumatology, Renji Hospital, Shanghai Second Medical University, Shanghai 200001, China.
出版信息
Chin Med J (Engl). 2000 Oct;113(10):877-80.
OBJECTIVE
To investigate the imbalance of Th1/Th2-type cytokines in patients with systemic lupus erythematosus (SLE) and its relation to disease activity.
METHODS
Intracellular cytokines were determined by flow-cytometry following whole-blood culture.
RESULTS
Patients with systemic lupus erythematosus disease activity index (SLEDAI) > 10 had statistically significantly fewer CD4+ or CD8+ T cells producing IFN-gamma than patients with SLEDAI = 0, SLEDAI 1-10 or healthy controls (P < 0.01, P < 0.01 or P < 0.05, respectively). Patients with SLEDAI > 10 also had decreased ratio of IFN-gamma/IL-4 positive CD4+ or CD8+ T cells, compared with patients with SLEDAI = 0, SLEDAI 1-10 or healthy controls (P < 0.05). The decreased Th1 or Tc1 cells and the ratios of IFN-gamma: IL-4 positive CD4+ T-cells were significantly correlated with disease activity (P < 0.05).
CONCLUSION
SLE is characterized by an imbalance of Th1/Th2 and Tc1/Tc2 cytokines. The decreased Th1 or Tc1 cells and the Th1/Th2 ratio are related to disease activity.
目的
研究系统性红斑狼疮（SLE）患者Th1/Th2型细胞因子失衡及其与疾病活动度的关系。
方法
全血培养后采用流式细胞术检测细胞内细胞因子。
结果
系统性红斑狼疮疾病活动指数（SLEDAI）>10的患者中，产生干扰素-γ的CD4+或CD8+T细胞数量在统计学上显著少于SLEDAI = 0、SLEDAI 1-10的患者或健康对照（分别为P < 0.01、P < 0.01或P < 0.05）。与SLEDAI = 0、SLEDAI 1-10的患者或健康对照相比，SLEDAI > 10的患者中干扰素-γ/白细胞介素-4阳性CD4+或CD8+T细胞的比例也降低（P < 0.05）。Th1或Tc1细胞减少以及干扰素-γ:白细胞介素-4阳性CD4+T细胞的比例与疾病活动度显著相关（P < 0.05）。
结论
SLE的特征是Th1/Th2和Tc1/Tc2细胞因子失衡。Th1或Tc1细胞减少以及Th1/Th2比例与疾病活动度有关。
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