Barbeito Claudio G, Albarenque Stella Maris, Reyna Juan C, Flamini Mirta A, Laube Pedro F Andrés, Badrán Amado F
Laboratory of Histology and Embryology, School of Veterinary Sciences, University of La Plata, Argentina.
Cell Biol Int. 2002;26(1):123-5. doi: 10.1006/cbir.2001.0824.
The presence of a tumor generally changes the mitotic activity of the normal cell population in mice. In the present work, the mitotic activity of the duodenal crypt enterocytes in EA21a mammary carcinoma-bearing mice was determined. The results show that there is a patent circadian variation in normal mice and, in the presence of the EA21a mammary tumor, cell proliferation is stimulated. Stimulation was evident in enterocytes from the intermediate as well as the superficial regions of the crypt. Some humoral factors produced by the transplanted tumor could interfere with the regulatory mechanism of the mitotic activity of duodenal crypt enterocytes.
肿瘤的存在通常会改变小鼠正常细胞群体的有丝分裂活性。在本研究中，测定了携带EA21a乳腺癌小鼠十二指肠隐窝肠上皮细胞的有丝分裂活性。结果表明，正常小鼠存在明显的昼夜节律变化，并且在EA21a乳腺肿瘤存在的情况下，细胞增殖受到刺激。在隐窝中间区域和表面区域的肠上皮细胞中，这种刺激作用很明显。移植肿瘤产生的一些体液因子可能会干扰十二指肠隐窝肠上皮细胞有丝分裂活性的调节机制。
