Cook Christine L, Siow Yong, Brenner Amy G, Fallat Mary E
Department of Obstetrics and Gynecology, University of Louisville, Louisville, Kentucky 40292, USA.
Fertil Steril. 2002 Jan;77(1):141-6. doi: 10.1016/s0015-0282(01)02944-2.
To examine the relationship of serum müllerian-inhibiting substance (MIS), E(2), free-T, LH, and FSH in untreated women with polycystic ovary syndrome (PCOS) and in women with normal menstrual cycles.
A prospective study.
University Departments of Obstetrics and Gynecology and Surgery.
PATIENT(S): Twenty-seven women with PCOS and 20 women with normal menstrual cycles.
INTERVENTION(S): Serum was collected from women with PCOS and from normal women during the early follicular phase of the menstrual cycle, stored frozen until assayed.
MAIN OUTCOME MEASURE(S): Serum levels of MIS, E(2), free-T, TSH, LH, and FSH were measured.
RESULT(S): Serum müllerian-inhibiting substance levels in PCOS patients were significantly higher compared with normal women (+/- SE; 5.3 +/- 0.7 and 1.4 +/- 0.2 ng/mL, respectively). An inverse correlation (r = -0.5965) was found between serum levels of MIS and E(2) in PCOS women, but not in normal women. Women with PCOS had higher serum LH levels than those of normal women (15.2 +/- 1.2 and 5.0 +/- 0.7 mIU/mL).
In this study, women with PCOS have significantly higher serum MIS levels than normal women. The inverse relationship between müllerian-inhibiting substance and E(2) levels suggests that MIS may modulate ovarian E(2) synthesis and have a role in the disordered folliculogenesis characteristic of PCOS.
研究未经治疗的多囊卵巢综合征（PCOS）女性及月经周期正常女性血清苗勒管抑制物质（MIS）、雌二醇（E₂）、游离睾酮（free - T）、促黄体生成素（LH）和促卵泡生成素（FSH）之间的关系。
一项前瞻性研究。
大学妇产科和外科系。
27例PCOS女性和20例月经周期正常的女性。
在月经周期的卵泡早期从PCOS女性和正常女性中采集血清，冷冻保存直至检测。
检测血清MIS、E₂、free - T、促甲状腺激素（TSH）、LH和FSH水平。
PCOS患者血清苗勒管抑制物质水平显著高于正常女性（±标准误；分别为5.3±0.7和1.4±0.2 ng/mL）。PCOS女性血清MIS水平与E₂之间存在负相关（r = -0.5965），而正常女性中未发现此相关性。PCOS女性血清LH水平高于正常女性（15.2±1.2和5.0±0.7 mIU/mL）。
在本研究中，PCOS女性血清MIS水平显著高于正常女性。苗勒管抑制物质与E₂水平之间的负相关表明，MIS可能调节卵巢E₂合成，并在PCOS特征性的卵泡发育异常中起作用。
