Siow Yong, Kives Sari, Hertweck Paige, Perlman Sally, Fallat Mary E
Department of Surgery, University of Louisville, Louisville, Kentucky, USA.
Fertil Steril. 2005 Oct;84(4):938-44. doi: 10.1016/j.fertnstert.2005.02.052.
To compare serum müllerian-inhibiting substance (MIS) concentrations in adolescent girls with polycystic ovary syndrome (PCOS) or normal menstrual cycles.
Prospective study.
University department of obstetrics and gynecology.
PATIENT(S): Thirty-one girls (12-18 years old) with PCOS and 17 girls (12-19 years old) with normal menstrual cycles.
INTERVENTION(S): Serum was collected from girls with PCOS or normal cycles during the early follicular phase of the menstrual cycle, stored frozen until assayed.
MAIN OUTCOME MEASURE(S): Serum levels of MIS, E2, free-T, androstenedione, LH, and FSH.
RESULT(S): Serum MIS levels in girls with PCOS were significantly higher compared with normal girls (4.1 +/- 2.2 [SD] and 2.4 +/- 1.0 ng/mL, respectively). The subjects were stratified for body mass index (BMI) (< and >25 kg/m2). Serum MIS levels in PCOS girls (4.2 +/- 3.0 ng/mL [BMI <25 kg/m2] and 4.0 +/- 1.6 [BMI >25 kg/m2]) were significantly higher compared with normal girls (2.2 +/- 0.8 and 2.6 +/- 0.7 ng/mL, respectively).
CONCLUSION(S): Adolescent girls with PCOS have significantly higher serum MIS levels compared with normally cycling girls. Serum MIS levels in PCOS were not influenced by BMI. Increased MIS production may represent an early manifestation of the disease.
比较患有多囊卵巢综合征（PCOS）的青春期女孩与月经周期正常的青春期女孩的血清苗勒管抑制物质（MIS）浓度。
前瞻性研究。
大学妇产科系。
31名患有PCOS的女孩（12 - 18岁）和17名月经周期正常的女孩（12 - 19岁）。
在月经周期的卵泡早期从患有PCOS或月经周期正常的女孩中采集血清，冷冻保存直至检测。
血清MIS、雌二醇（E2）、游离睾酮（free - T）、雄烯二酮、促黄体生成素（LH）和促卵泡生成素（FSH）水平。
患有PCOS的女孩血清MIS水平显著高于正常女孩（分别为4.1±2.2[标准差]和2.4±1.0 ng/mL）。根据体重指数（BMI）（<和>25 kg/m²）对受试者进行分层。患有PCOS的女孩血清MIS水平（BMI<25 kg/m²时为4.2±3.0 ng/mL，BMI>25 kg/m²时为4.0±1.6）显著高于正常女孩（分别为2.2±0.8和2.6±0.7 ng/mL）。
患有PCOS的青春期女孩血清MIS水平显著高于月经周期正常的女孩。PCOS患者的血清MIS水平不受BMI影响。MIS产生增加可能是该疾病的早期表现。
