类风湿关节炎、强直性脊柱炎和骨关节炎患者的血清硝酸盐和亚硝酸盐水平。

Serum nitrate and nitrite levels in patients with rheumatoid arthritis, ankylosing spondylitis, and osteoarthritis.

作者信息

Ersoy Y, Ozerol E, Baysal O, Temel I, MacWalter R S, Meral U, Altay Z E

机构信息

Department of Physical Medicine and Rehabilitation, Inonu University Faculty of Medicine, Turgut Ozal Medical Centre, 44069 Malatya, Turkey.

出版信息

Ann Rheum Dis. 2002 Jan;61(1):76-8. doi: 10.1136/ard.61.1.76.

DOI:10.1136/ard.61.1.76

PMID:11779766

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1753884/

Abstract

OBJECTIVE

To assess and compare serum nitrate and nitrite levels in patients with ankylosing spondylitis (AS), rheumatoid arthritis (RA), and osteoarthritis (OA).

METHODS

Thirty five patients with RA, 32 patients with AS, and 36 patients with OA were entered into this study. In addition, 30 healthy volunteers acted as a control group. Concentrations of nitrate and nitrite in serum were determined by direct and indirect Griess reactions. C reactive protein and erythrocyte sedimentation rate levels were determined as markers of systemic activity of disease (SAD) in RA and AS groups.

RESULTS

Serum nitrate and nitrite levels were found to be higher in patients with AS and RA than in the OA group (p<0.01). In addition, serum nitrate and nitrite levels were higher in all three groups than in the control group (p<0.01). Moreover, serum nitrate and nitrite levels were higher in patients who had SAD than in those who had not in the RA and AS groups (p<0.01 and p<0.05, respectively), and there was a correlation between serum nitrate and nitrite concentrations and SAD variables in patients with RA (Spearman's r(s)=0.414, p<0.05 and r(s)=0.408, p<0.05, respectively) and AS (r(s)=0.421, p<0.05 and r(s)=0.412, p<0.05, respectively).

CONCLUSION

The findings suggest that nitrate and nitrite production is enhanced in patients with inflammatory arthritis compared with OA. In addition, serum nitrate and nitrite levels are enhanced in patients with RA, AS, and OA compared with healthy subjects. Furthermore, there is a correlation between the SAD variables and serum nitrate and nitrite levels in patients with RA and AS.

摘要

目的

评估并比较强直性脊柱炎（AS）、类风湿关节炎（RA）和骨关节炎（OA）患者的血清硝酸盐和亚硝酸盐水平。

方法

本研究纳入了35例RA患者、32例AS患者和36例OA患者。此外，30名健康志愿者作为对照组。采用直接和间接格里斯反应测定血清中硝酸盐和亚硝酸盐的浓度。测定RA和AS组中C反应蛋白和红细胞沉降率水平作为疾病全身活动（SAD）的标志物。

结果

发现AS和RA患者的血清硝酸盐和亚硝酸盐水平高于OA组（p<0.01）。此外，所有三组患者的血清硝酸盐和亚硝酸盐水平均高于对照组（p<0.01）。而且，RA和AS组中出现SAD的患者血清硝酸盐和亚硝酸盐水平高于未出现SAD的患者（分别为p<0.01和p<0.05），并且RA患者（Spearman's r(s)=0.414，p<0.05和r(s)=0.408，p<0.05）和AS患者（r(s)=0.421，p<0.05和r(s)=0.412，p<0.05）血清硝酸盐和亚硝酸盐浓度与SAD变量之间存在相关性。