Huang Heqing, Yu Bing, Liu Wen, Lin Qingyan, Chen Liying, Chen Juan, Duan Lihua, Shi Guixiu
Department of Rheumatology and Clinical Immunology, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Medicine (Baltimore). 2017 Apr;96(17):e6780. doi: 10.1097/MD.0000000000006780.
To analyze the alteration of lipid profile and inflammatory markers in the serum of patients with gouty arthritis (GA), the levels of serum lipid profile, C-reactive protein (CRP), and erythrocyte sedimentation rates (ESRs) were measured in the serum of 69 gout patients, 35 patients with rheumatoid arthritis (RA), 23 patients with ankylosing spondylitis (AS)/spondyloarthropathy (SpA), and 25 patients with osteoarthritis (OA). The serum levels of apoprotein A1 (Apo-A1) were significantly decreased in patients with gout when compared with RA, AS/SpA, and OA patients. The serum levels of CRP were significantly increased in gouty patients when compared with RA, AS/SpA, and OA patients. Furthermore, the serum levels of ESR were significantly increased in patients with gout compared to patients with OA. Correlation analysis indicated that the levels of Apo-A1 were negatively correlated with serum ESR and CRP (r = -0.475, P < .001; r = -0.380, P = .001, respectively) in the patients with GA. Taken together, this study gives us a better understanding of the relationships between serum lipid profile and inflammatory markers in gout patients.
为分析痛风性关节炎（GA）患者血清中脂质谱和炎症标志物的变化，对69例痛风患者、35例类风湿关节炎（RA）患者、23例强直性脊柱炎（AS）/脊柱关节病（SpA）患者和25例骨关节炎（OA）患者的血清进行了脂质谱、C反应蛋白（CRP）和红细胞沉降率（ESR）水平的检测。与RA、AS/SpA和OA患者相比，痛风患者血清载脂蛋白A1（Apo-A1）水平显著降低。与RA、AS/SpA和OA患者相比，痛风患者血清CRP水平显著升高。此外，与OA患者相比，痛风患者血清ESR水平显著升高。相关性分析表明，GA患者中Apo-A1水平与血清ESR和CRP呈负相关（r = -0.475，P < 0.001；r = -0.380，P = 0.001）。综上所述，本研究让我们对痛风患者血清脂质谱与炎症标志物之间的关系有了更好的了解。
