Korkmaz C, Ozdogan H, Kasapçopur O, Yazici H
Department of Rheumatology, Medical School of Osmangazi University, Eskisehir, Turkey.
Ann Rheum Dis. 2002 Jan;61(1):79-81. doi: 10.1136/ard.61.1.79.
To test the hypothesis that not all acute phase reactants respond in the same way during attacks of familial Mediterranean fever (FMF) and that there is a subclinical acute phase response (APR) in a proportion of patients during the interval between attacks.
Blood and urine samples were obtained from 49 patients with FMF during an attack and the attack-free period that followed, to test for erythrocyte sedimentation rate, C reactive protein (CRP), fibrinogen, white blood cell count, platelet count, factor VIII related antigen, haptoglobin, protein electrophoresis, ferritin, proteinuria, and haematuria. Control groups comprised 29 patients with juvenile idiopathic arthritis, 10 patients with various infectious diseases, and 19 healthy subjects.
A marked APR was seen during the FMF attacks which was comparable with that obtained in the diseased control groups. CRP was the only acute phase protein that was raised during all attacks. Neither thrombocytosis nor an increase in ferritin levels (except one) was noted in any attack. Serum albumin levels remained unchanged. In two thirds of the patients with FMF a continuing APR was seen in between the attacks.
Platelet, ferritin, and albumin responses are not part of the significant APR seen during short lived attacks of FMF, and inflammation continues in about two thirds of the patients during an attack-free period.
验证以下假设，即在家族性地中海热（FMF）发作期间，并非所有急性期反应物的反应方式都相同，且在发作间期一部分患者存在亚临床急性期反应（APR）。
采集49例FMF患者在发作期及随后的缓解期的血液和尿液样本，检测红细胞沉降率、C反应蛋白（CRP）、纤维蛋白原、白细胞计数、血小板计数、凝血因子VIII相关抗原、触珠蛋白、蛋白电泳、铁蛋白、蛋白尿和血尿。对照组包括29例幼年特发性关节炎患者、10例患有各种传染病的患者和19名健康受试者。
FMF发作期间可见明显的APR，与患病对照组的情况相当。CRP是在所有发作期间均升高的唯一急性期蛋白。在任何一次发作中均未观察到血小板增多或铁蛋白水平升高（仅1例除外）。血清白蛋白水平保持不变。三分之二的FMF患者在发作间期可见持续的APR。
血小板、铁蛋白和白蛋白反应并非FMF短暂发作期间明显APR的一部分，且约三分之二的患者在缓解期仍存在炎症。
