Yan J, Fang Y, Liang Q, Huang Y, Zeng Y
Department of Aetiology, Cancer Institute, Cancer Center, Sun Yat-sen University of Medical Sciences, Guangzhou 510060, China.
Chin Med J (Engl). 2001 Apr;114(4):418-21.
To gain a better understanding of genetic changes in Cantonese nasopharyngeal carcinoma (NPC).
Comparative genomic hybridization (CGH) was performed on 17 primary nasopharyngeal carcinomas.
A novel copy number gain an chromosome 4q and loss of chromosome 1p were found at a high frequency (> 50%).
Current analysis revealed a comprehensive profile of the chromosomal regions showing gain of chromosomes 4q, 12q, and 1q as well as loss of chromosomes 1p, 3p, 11q, 14q, 15q, 13q, Xq, 9q, 10p, 10q, and 16q. Frequently altered loci may encode oncogenes or tumor suppressor genes involved in the development of primary NPC.
更好地了解粤语人群鼻咽癌（NPC）的基因变化。
对17例原发性鼻咽癌进行比较基因组杂交（CGH）分析。
发现4号染色体长臂存在新的拷贝数增加，1号染色体短臂缺失，且频率较高（>50%）。
目前的分析揭示了染色体区域的综合图谱，显示4号染色体长臂、12号染色体长臂和1号染色体长臂有增加，而1号染色体短臂、3号染色体短臂、11号染色体长臂、14号染色体长臂、15号染色体长臂、13号染色体长臂、X染色体长臂、9号染色体长臂、10号染色体短臂、10号染色体长臂和16号染色体长臂有缺失。频繁改变的位点可能编码参与原发性鼻咽癌发生发展的癌基因或肿瘤抑制基因。
