Younes Husam M, Amsden Brian G
Faculty of Pharmacy and Pharmaceutical Science, University of Alberta, Edmonton, Alberta T6G 2N8, Canada.
J Pharm Sci. 2002 Jan;91(1):2-17. doi: 10.1002/jps.10007.
Although different routes and delivery systems have been used to deliver interferon-gamma (IFN-gamma) for the treatment of a variety of viral and neoplastic diseases, little has been reported regarding the most efficient and least toxic routes and drug delivery modes required to achieve these goals. To have a greater understanding of the best strategies to use to administer this cytokine in an efficient, stable, and safe manner, this review details aspects of IFN-gamma concerning its mechanism of action, physical properties, and pharmacokinetics. One important conclusion that is drawn from this analysis is that a consistent, local concentration of IFN-gamma is necessary to achieve an optimal therapeutic response. A critical discussion covering the advantages and limitations of the currently used methodologies to deliver IFN-gamma in such a fashion is presented.
尽管已采用不同途径和递送系统来递送γ干扰素（IFN-γ）以治疗多种病毒和肿瘤疾病，但关于实现这些目标所需的最有效且毒性最小的途径和药物递送模式，鲜有报道。为了更深入了解以高效、稳定和安全的方式施用这种细胞因子的最佳策略，本综述详细介绍了IFN-γ在其作用机制、物理性质和药代动力学方面的情况。从该分析得出的一个重要结论是，需要有持续的局部IFN-γ浓度才能实现最佳治疗反应。本文还对目前用于以这种方式递送IFN-γ的方法的优缺点进行了批判性讨论。
