Shaker Mohamed A, Younes Husam M
School of Pharmacy, Memorial University of Newfoundland, St. John's, Newfoundland, Canada.
J Pharm Sci. 2009 Jul;98(7):2268-98. doi: 10.1002/jps.21596.
Despite the fact that different administration routes and delivery systems have been used for interleukin-2 (IL-2) delivery, little has been reported regarding the most efficient strategies used to deliver IL-2 in a nontoxic, efficient, stable and safe manner. Systemic IL-2 administration has always been associated with rapid clearance and severe toxicity as a result of its narrow therapeutic index. Loco-regional IL-2 delivery, however, is used to localize IL-2 actions and activities into the vicinity of tumors and can result in an improved therapeutic outcome with much less side effects or toxicity. The purpose of this review is to report on the different properties and aspects of IL-2, including its mechanism of action, physicochemical properties, and structure which have an impact on the activity, stability and formulation of IL-2 dosage forms and delivery systems. In addition, advantages and limitations of the currently available techniques and strategies to deliver IL-2 will also be covered.
尽管已经采用了不同的给药途径和递送系统来递送白细胞介素-2（IL-2），但关于以无毒、高效、稳定和安全的方式递送IL-2的最有效策略的报道却很少。由于其治疗指数狭窄，全身性IL-2给药一直与快速清除和严重毒性相关。然而，局部区域IL-2递送用于将IL-2的作用和活性定位在肿瘤附近，并且可以在副作用或毒性小得多的情况下产生改善的治疗效果。本综述的目的是报告IL-2的不同特性和方面，包括其作用机制、物理化学性质以及对IL-2剂型和递送系统的活性、稳定性和制剂有影响的结构。此外，还将涵盖目前可用的IL-2递送技术和策略的优点和局限性。
