del Castillo F, Ledesma F, García-Perea A
Pediatric Infectious Disease Unit, Children's University Hospital La Paz, Madrid, Spain.
Eur J Clin Microbiol Infect Dis. 2001 Nov;20(11):824-6. doi: 10.1007/s100960100608.
Resistance to erythromycin is usually associated with resistance to penicillin in Streptococcus pneumoniae isolates. Over the last few years, however, an increase has been detected in the number of Streptococcus pneumoniae isolates obtained from children with acute otitis media complicated by acute mastoiditis. These isolates are characterized by a penicillin-susceptible and erythromycin-resistant antibiotic profile. This observation prompted a review of the microbiology database and analysis of all Streptococcus pneumoniae isolates with this peculiar antibiotic profile at a university hospital in Madrid, Spain.
在肺炎链球菌分离株中，对红霉素的耐药性通常与对青霉素的耐药性相关。然而，在过去几年中，从患有急性中耳炎并发急性乳突炎的儿童中分离出的肺炎链球菌数量有所增加。这些分离株的特征是对青霉素敏感而对红霉素耐药的抗生素谱。这一观察结果促使对西班牙马德里一家大学医院的微生物学数据库进行回顾，并对所有具有这种特殊抗生素谱的肺炎链球菌分离株进行分析。
